Performances assessment of Anipill device prototype designed for continuous temperature monitoring

This study aimed to test the validity and reliability of the latest version of the Anipill device including a calibration assessment step and an in-vivo testing in rodents. After performing a calibration procedure, 10 rats were intraperitoneally implanted with a pair of sensors, one Anipill (8.2 mm diameter, 17.2 mm length) and one Jonah (8.7 mm diameter, 23 mm length). Temperature data were collected and compared during both a 24 h period of free ranging and after an injection of Lipopolysaccharide d'Escherichia coli, serotype 0111:B4 (LPS) and Apomorphine hydrochloride. Furthermore, the transmission distance of Anipill was assessed by moving the animal compound away from the data logger. The results of the calibration process indicate a significant average difference between Anipill and Jonah of .04 .04 °C. During free ranging, the mean inter-sensors difference observed was −.1 .1 °C. Nevertheless, the instantaneous difference values between devices could sometimes reach .96 °C (.2 < 90% interquantile range