KCC2 overexpressed exosomes meditated spinal cord injury recovery in mice

Exosomes show great potential in treating diseases of the central nervous system including spinal cord injury (SCI), still better engineered exosomes have more advantages. In this study, we purified exosomes from K -Cl co-transporter (KCC2) overexpressed bone marrow mesenchymal stem cells (Exo ), to investigate the effect of Exo on neural differentiation and the repairing function of Exo in SCI mice . Compared to bone marrow mesenchymal stem cells (BMSC)-derived exosomes (Exo), Exo could better promote neural stem cell differentiated into neurons, ameliorate the function recovery of SCI mice, and accelerate the neural regeneration at the lesion site. Altogether, engineered Exo may prove to be an advantageous strategy for SCI treatment.