Biomineralization guided by polydopamine-modifed poly(L-lactide) fibrous membrane for promoted osteoconductive activity
A method to mediate biomineralization of electrospinning poly(L-lactide) (PLLA) fibrous membrane assisted by polydopamine (PDA) coating was developed to obtain enhanced osteoconductive activity. The biomineralization mechanism, surface composition, morphology and hydrophilicity of the original and m...
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| Veröffentlicht in: | Biomedical materials (Bristol) 2019-07, Vol.14 (5), p.055005-055005 |
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| creator | Chen, Xuexing Zhu, Ling Liu, Hua Wen, Wei Li, Hong Zhou, Changren Luo, Binghong |
| description | A method to mediate biomineralization of electrospinning poly(L-lactide) (PLLA) fibrous membrane assisted by polydopamine (PDA) coating was developed to obtain enhanced osteoconductive activity. The biomineralization mechanism, surface composition, morphology and hydrophilicity of the original and modified PLLA fibrous membranes were characterized. Results revealed that the PDA coating effectively accelerated the formation of hydroxyapatite (HA) on PLLA fibrous membrane and resulted a great increase in hydrophilicity. Moreover, the tensile property of PLLA fibrous membrane was enhanced by the PDA coating while almost kept unchanged by further immobilized with HA. Cells culture results indicated that the successive introduction of PDA and HA contributed to an obvious improvement in the adhesion and proliferation, as well as up-regulated alkaline phosphatase (ALP) activity and promoted osteogenic-related genes and proteins expression of MC3T3-E1 cells. Overall, the as-prepared PLLA-PDA-HA fibrous membrane can be expected as a favorable scaffold for bone tissue repair. |
| doi_str_mv | 10.1088/1748-605X/ab2f2d |
| format | Article |
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The biomineralization mechanism, surface composition, morphology and hydrophilicity of the original and modified PLLA fibrous membranes were characterized. Results revealed that the PDA coating effectively accelerated the formation of hydroxyapatite (HA) on PLLA fibrous membrane and resulted a great increase in hydrophilicity. Moreover, the tensile property of PLLA fibrous membrane was enhanced by the PDA coating while almost kept unchanged by further immobilized with HA. Cells culture results indicated that the successive introduction of PDA and HA contributed to an obvious improvement in the adhesion and proliferation, as well as up-regulated alkaline phosphatase (ALP) activity and promoted osteogenic-related genes and proteins expression of MC3T3-E1 cells. Overall, the as-prepared PLLA-PDA-HA fibrous membrane can be expected as a favorable scaffold for bone tissue repair.</description><identifier>ISSN: 1748-605X</identifier><identifier>EISSN: 1748-605X</identifier><identifier>DOI: 10.1088/1748-605X/ab2f2d</identifier><identifier>PMID: 31271155</identifier><identifier>CODEN: BMBUCS</identifier><language>eng</language><publisher>England: IOP Publishing</publisher><subject>3T3 Cells ; Alkaline Phosphatase - metabolism ; Animals ; Biomineralization ; Bone Regeneration ; Bone Substitutes - chemistry ; Cell Adhesion ; Cell Proliferation ; Durapatite - chemistry ; Gene Expression Profiling ; Indoles - chemistry ; Materials Testing ; Mice ; osteoconductive activity ; Osteogenesis ; poly(L-lactide) ; polydopamine ; Polyesters - chemistry ; Polymers - chemistry ; Spectroscopy, Fourier Transform Infrared ; surface modification ; Surface Properties ; Tensile Strength ; Thermogravimetry ; Tissue Scaffolds ; X-Ray Diffraction</subject><ispartof>Biomedical materials (Bristol), 2019-07, Vol.14 (5), p.055005-055005</ispartof><rights>2019 IOP Publishing Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-fc3d442c55cf06303b6a6a5bb3ef5845b58de97bc7dc78e9fc91bb3a48a1e8473</citedby><cites>FETCH-LOGICAL-c405t-fc3d442c55cf06303b6a6a5bb3ef5845b58de97bc7dc78e9fc91bb3a48a1e8473</cites><orcidid>0000-0001-8689-4196</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.1088/1748-605X/ab2f2d/pdf$$EPDF$$P50$$Giop$$H</linktopdf><link.rule.ids>314,776,780,27903,27904,53824,53871</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31271155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Xuexing</creatorcontrib><creatorcontrib>Zhu, Ling</creatorcontrib><creatorcontrib>Liu, Hua</creatorcontrib><creatorcontrib>Wen, Wei</creatorcontrib><creatorcontrib>Li, Hong</creatorcontrib><creatorcontrib>Zhou, Changren</creatorcontrib><creatorcontrib>Luo, Binghong</creatorcontrib><title>Biomineralization guided by polydopamine-modifed poly(L-lactide) fibrous membrane for promoted osteoconductive activity</title><title>Biomedical materials (Bristol)</title><addtitle>BMM</addtitle><addtitle>Biomed. Mater</addtitle><description>A method to mediate biomineralization of electrospinning poly(L-lactide) (PLLA) fibrous membrane assisted by polydopamine (PDA) coating was developed to obtain enhanced osteoconductive activity. The biomineralization mechanism, surface composition, morphology and hydrophilicity of the original and modified PLLA fibrous membranes were characterized. Results revealed that the PDA coating effectively accelerated the formation of hydroxyapatite (HA) on PLLA fibrous membrane and resulted a great increase in hydrophilicity. Moreover, the tensile property of PLLA fibrous membrane was enhanced by the PDA coating while almost kept unchanged by further immobilized with HA. Cells culture results indicated that the successive introduction of PDA and HA contributed to an obvious improvement in the adhesion and proliferation, as well as up-regulated alkaline phosphatase (ALP) activity and promoted osteogenic-related genes and proteins expression of MC3T3-E1 cells. Overall, the as-prepared PLLA-PDA-HA fibrous membrane can be expected as a favorable scaffold for bone tissue repair.</description><subject>3T3 Cells</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>Animals</subject><subject>Biomineralization</subject><subject>Bone Regeneration</subject><subject>Bone Substitutes - chemistry</subject><subject>Cell Adhesion</subject><subject>Cell Proliferation</subject><subject>Durapatite - chemistry</subject><subject>Gene Expression Profiling</subject><subject>Indoles - chemistry</subject><subject>Materials Testing</subject><subject>Mice</subject><subject>osteoconductive activity</subject><subject>Osteogenesis</subject><subject>poly(L-lactide)</subject><subject>polydopamine</subject><subject>Polyesters - chemistry</subject><subject>Polymers - chemistry</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>surface modification</subject><subject>Surface Properties</subject><subject>Tensile Strength</subject><subject>Thermogravimetry</subject><subject>Tissue Scaffolds</subject><subject>X-Ray Diffraction</subject><issn>1748-605X</issn><issn>1748-605X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9LwzAcxYMobk7vnqQ3J1iXtMnaHnX4CwZeFLyF_JSMpqlJO5l_vSmb4kFPCS-f983LCwCnCF4hWJYzVOAynUPyOmM805ncA-Mfaf_XfgSOQlhBSCqSV4dglKOsQIiQMfi4Mc6aRnlWm0_WGdckb72RSiZ8k7Su3kjXsgFIrZNGR30Qp8u0ZqKL3EWiDfeuD4lVlnvWqEQ7n7TeWddF2oVOOeEa2Ud8rZLBtTbd5hgcaFYHdbJbJ-Dl7vZ58ZAun-4fF9fLVGBIulSLXGKcCUKEhvMc5nzO5oxwnitNSkw4KaWqCi4KKYpSVVpUKB4yXDKkSlzkEzDdzo2J3nsVOmpNEKquY9KYmmYZyTKcQ4QiCreo8C4ErzRtvbHMbyiCdKibDn3SoU-6rTtaznbTe26V_DF89xuB8y1gXEtXrvdNfCzl1lKEKaGQkPgptJU6kpd_kP_e_AVgsZsA</recordid><startdate>20190719</startdate><enddate>20190719</enddate><creator>Chen, Xuexing</creator><creator>Zhu, Ling</creator><creator>Liu, Hua</creator><creator>Wen, Wei</creator><creator>Li, Hong</creator><creator>Zhou, Changren</creator><creator>Luo, Binghong</creator><general>IOP Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8689-4196</orcidid></search><sort><creationdate>20190719</creationdate><title>Biomineralization guided by polydopamine-modifed poly(L-lactide) fibrous membrane for promoted osteoconductive activity</title><author>Chen, Xuexing ; Zhu, Ling ; Liu, Hua ; Wen, Wei ; Li, Hong ; Zhou, Changren ; Luo, Binghong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-fc3d442c55cf06303b6a6a5bb3ef5845b58de97bc7dc78e9fc91bb3a48a1e8473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>3T3 Cells</topic><topic>Alkaline Phosphatase - metabolism</topic><topic>Animals</topic><topic>Biomineralization</topic><topic>Bone Regeneration</topic><topic>Bone Substitutes - chemistry</topic><topic>Cell Adhesion</topic><topic>Cell Proliferation</topic><topic>Durapatite - chemistry</topic><topic>Gene Expression Profiling</topic><topic>Indoles - chemistry</topic><topic>Materials Testing</topic><topic>Mice</topic><topic>osteoconductive activity</topic><topic>Osteogenesis</topic><topic>poly(L-lactide)</topic><topic>polydopamine</topic><topic>Polyesters - chemistry</topic><topic>Polymers - chemistry</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>surface modification</topic><topic>Surface Properties</topic><topic>Tensile Strength</topic><topic>Thermogravimetry</topic><topic>Tissue Scaffolds</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Xuexing</creatorcontrib><creatorcontrib>Zhu, Ling</creatorcontrib><creatorcontrib>Liu, Hua</creatorcontrib><creatorcontrib>Wen, Wei</creatorcontrib><creatorcontrib>Li, Hong</creatorcontrib><creatorcontrib>Zhou, Changren</creatorcontrib><creatorcontrib>Luo, Binghong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedical materials (Bristol)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Xuexing</au><au>Zhu, Ling</au><au>Liu, Hua</au><au>Wen, Wei</au><au>Li, Hong</au><au>Zhou, Changren</au><au>Luo, Binghong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomineralization guided by polydopamine-modifed poly(L-lactide) fibrous membrane for promoted osteoconductive activity</atitle><jtitle>Biomedical materials (Bristol)</jtitle><stitle>BMM</stitle><addtitle>Biomed. Mater</addtitle><date>2019-07-19</date><risdate>2019</risdate><volume>14</volume><issue>5</issue><spage>055005</spage><epage>055005</epage><pages>055005-055005</pages><issn>1748-605X</issn><eissn>1748-605X</eissn><coden>BMBUCS</coden><abstract>A method to mediate biomineralization of electrospinning poly(L-lactide) (PLLA) fibrous membrane assisted by polydopamine (PDA) coating was developed to obtain enhanced osteoconductive activity. The biomineralization mechanism, surface composition, morphology and hydrophilicity of the original and modified PLLA fibrous membranes were characterized. Results revealed that the PDA coating effectively accelerated the formation of hydroxyapatite (HA) on PLLA fibrous membrane and resulted a great increase in hydrophilicity. Moreover, the tensile property of PLLA fibrous membrane was enhanced by the PDA coating while almost kept unchanged by further immobilized with HA. Cells culture results indicated that the successive introduction of PDA and HA contributed to an obvious improvement in the adhesion and proliferation, as well as up-regulated alkaline phosphatase (ALP) activity and promoted osteogenic-related genes and proteins expression of MC3T3-E1 cells. Overall, the as-prepared PLLA-PDA-HA fibrous membrane can be expected as a favorable scaffold for bone tissue repair.</abstract><cop>England</cop><pub>IOP Publishing</pub><pmid>31271155</pmid><doi>10.1088/1748-605X/ab2f2d</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-8689-4196</orcidid></addata></record> |
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| subjects | 3T3 Cells Alkaline Phosphatase - metabolism Animals Biomineralization Bone Regeneration Bone Substitutes - chemistry Cell Adhesion Cell Proliferation Durapatite - chemistry Gene Expression Profiling Indoles - chemistry Materials Testing Mice osteoconductive activity Osteogenesis poly(L-lactide) polydopamine Polyesters - chemistry Polymers - chemistry Spectroscopy, Fourier Transform Infrared surface modification Surface Properties Tensile Strength Thermogravimetry Tissue Scaffolds X-Ray Diffraction |
| title | Biomineralization guided by polydopamine-modifed poly(L-lactide) fibrous membrane for promoted osteoconductive activity |
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