Comparison of bolus- and filtering-based EIT measures of lung perfusion in an animal model

Objective: Two main functional imaging approaches have been used to measure regional lung perfusion using electrical impedance tomography (EIT): venous injection of a hypertonic saline contrast agent and imaging of its passage through the heart and lungs, and digital filtering of heart-frequency imp...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Physiological measurement 2019-06, Vol.40 (5), p.054002-054002
Hauptverfasser: Stowe, Symon, Boyle, Alistair, Sage, Michaël, See, Wendy, Praud, Jean-Paul, Fortin-Pellerin, Étienne, Adler, Andy
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 054002
container_issue 5
container_start_page 054002
container_title Physiological measurement
container_volume 40
creator Stowe, Symon
Boyle, Alistair
Sage, Michaël
See, Wendy
Praud, Jean-Paul
Fortin-Pellerin, Étienne
Adler, Andy
description Objective: Two main functional imaging approaches have been used to measure regional lung perfusion using electrical impedance tomography (EIT): venous injection of a hypertonic saline contrast agent and imaging of its passage through the heart and lungs, and digital filtering of heart-frequency impedance changes over sequences of EIT images. This paper systematically compares filtering-based perfusion estimates and bolus injection methods to determine to which degree they are related. Approach: EIT data was recorded on seven mechanically ventilated newborn lambs in which ventilation distribution was varied through changes in posture between prone, supine, left- and right-lateral positions. Perfusion images were calculated using frequency filtering and ensemble averaging during both ventilation and apnoea time segments for each posture to compare against contrast agent-based methods using Jaccard distance score. Main results: Using bolus-based EIT measures of lung perfusion as the reference frequency filtering techniques performed better than ensemble averaging and both techniques performed equally well across apnoea and ventilation data segments. Significance: Our results indicate the potential for use of filtering-based EIT measures of heart-frequency activity as a non-invasive proxy for contrast agent injection-based measures of lung perfusion.
doi_str_mv 10.1088/1361-6579/ab1794
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1088_1361_6579_ab1794</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2207170329</sourcerecordid><originalsourceid>FETCH-LOGICAL-c336t-4ccf8297024d660db95f466b64b1d7dde5bf3021c1033a4afb39c848630639ae3</originalsourceid><addsrcrecordid>eNp9kEFLwzAYhoMobk7vnqRHD9YlTZq2RxlTBwMv8-IlJE0yMtKmJu3Bf29K5w6CwgeBL-_z8vEAcIvgI4JluUSYopTmRbXkAhUVOQPz0-oczGFFixRjTGbgKoQDhAiVWX4JZjj-5BiROfhYuabj3gTXJk4nwtkhpAlvZaKN7ZU37T4VPCiZrDe7pFE8DF6FMWqHdp90yushmAibNlJxTMNt0jip7DW40NwGdXN8F-D9eb1bvabbt5fN6mmb1hjTPiV1rcusKmBGJKVQiirXhFJBiUCykFLlQmOYoRpBjDnhWuCqLklJMaS44govwP3U23n3OajQs8aEWlnLW-WGwLIMFqiAOKtiFE7R2rsQvNKs8_Fg_8UQZKNRNupjoz42GY3I3bF9EI2SJ-BHYQzQX5216XkfnfSeG_tf88MEGtexgxt8Gy39Hf8GbL-PuQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2207170329</pqid></control><display><type>article</type><title>Comparison of bolus- and filtering-based EIT measures of lung perfusion in an animal model</title><source>MEDLINE</source><source>HEAL-Link subscriptions: Institute of Physics (IOP) Journals</source><source>Institute of Physics Journals</source><creator>Stowe, Symon ; Boyle, Alistair ; Sage, Michaël ; See, Wendy ; Praud, Jean-Paul ; Fortin-Pellerin, Étienne ; Adler, Andy</creator><creatorcontrib>Stowe, Symon ; Boyle, Alistair ; Sage, Michaël ; See, Wendy ; Praud, Jean-Paul ; Fortin-Pellerin, Étienne ; Adler, Andy</creatorcontrib><description>Objective: Two main functional imaging approaches have been used to measure regional lung perfusion using electrical impedance tomography (EIT): venous injection of a hypertonic saline contrast agent and imaging of its passage through the heart and lungs, and digital filtering of heart-frequency impedance changes over sequences of EIT images. This paper systematically compares filtering-based perfusion estimates and bolus injection methods to determine to which degree they are related. Approach: EIT data was recorded on seven mechanically ventilated newborn lambs in which ventilation distribution was varied through changes in posture between prone, supine, left- and right-lateral positions. Perfusion images were calculated using frequency filtering and ensemble averaging during both ventilation and apnoea time segments for each posture to compare against contrast agent-based methods using Jaccard distance score. Main results: Using bolus-based EIT measures of lung perfusion as the reference frequency filtering techniques performed better than ensemble averaging and both techniques performed equally well across apnoea and ventilation data segments. Significance: Our results indicate the potential for use of filtering-based EIT measures of heart-frequency activity as a non-invasive proxy for contrast agent injection-based measures of lung perfusion.</description><identifier>ISSN: 0967-3334</identifier><identifier>ISSN: 1361-6579</identifier><identifier>EISSN: 1361-6579</identifier><identifier>DOI: 10.1088/1361-6579/ab1794</identifier><identifier>PMID: 30965314</identifier><identifier>CODEN: PMEAE3</identifier><language>eng</language><publisher>England: IOP Publishing</publisher><subject>Animals ; Electric Impedance ; electrical impedance tomography ; Lung - physiology ; lung perfusion ; Models, Animal ; Perfusion ; Sheep ; Tomography ; ventilation</subject><ispartof>Physiological measurement, 2019-06, Vol.40 (5), p.054002-054002</ispartof><rights>2019 Institute of Physics and Engineering in Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c336t-4ccf8297024d660db95f466b64b1d7dde5bf3021c1033a4afb39c848630639ae3</citedby><cites>FETCH-LOGICAL-c336t-4ccf8297024d660db95f466b64b1d7dde5bf3021c1033a4afb39c848630639ae3</cites><orcidid>0000-0002-2312-5346 ; 0000-0002-4453-1511 ; 0000-0002-2738-2446</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.1088/1361-6579/ab1794/pdf$$EPDF$$P50$$Giop$$H</linktopdf><link.rule.ids>314,780,784,27924,27925,53846,53893</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30965314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stowe, Symon</creatorcontrib><creatorcontrib>Boyle, Alistair</creatorcontrib><creatorcontrib>Sage, Michaël</creatorcontrib><creatorcontrib>See, Wendy</creatorcontrib><creatorcontrib>Praud, Jean-Paul</creatorcontrib><creatorcontrib>Fortin-Pellerin, Étienne</creatorcontrib><creatorcontrib>Adler, Andy</creatorcontrib><title>Comparison of bolus- and filtering-based EIT measures of lung perfusion in an animal model</title><title>Physiological measurement</title><addtitle>PM</addtitle><addtitle>Physiol. Meas</addtitle><description>Objective: Two main functional imaging approaches have been used to measure regional lung perfusion using electrical impedance tomography (EIT): venous injection of a hypertonic saline contrast agent and imaging of its passage through the heart and lungs, and digital filtering of heart-frequency impedance changes over sequences of EIT images. This paper systematically compares filtering-based perfusion estimates and bolus injection methods to determine to which degree they are related. Approach: EIT data was recorded on seven mechanically ventilated newborn lambs in which ventilation distribution was varied through changes in posture between prone, supine, left- and right-lateral positions. Perfusion images were calculated using frequency filtering and ensemble averaging during both ventilation and apnoea time segments for each posture to compare against contrast agent-based methods using Jaccard distance score. Main results: Using bolus-based EIT measures of lung perfusion as the reference frequency filtering techniques performed better than ensemble averaging and both techniques performed equally well across apnoea and ventilation data segments. Significance: Our results indicate the potential for use of filtering-based EIT measures of heart-frequency activity as a non-invasive proxy for contrast agent injection-based measures of lung perfusion.</description><subject>Animals</subject><subject>Electric Impedance</subject><subject>electrical impedance tomography</subject><subject>Lung - physiology</subject><subject>lung perfusion</subject><subject>Models, Animal</subject><subject>Perfusion</subject><subject>Sheep</subject><subject>Tomography</subject><subject>ventilation</subject><issn>0967-3334</issn><issn>1361-6579</issn><issn>1361-6579</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFLwzAYhoMobk7vnqRHD9YlTZq2RxlTBwMv8-IlJE0yMtKmJu3Bf29K5w6CwgeBL-_z8vEAcIvgI4JluUSYopTmRbXkAhUVOQPz0-oczGFFixRjTGbgKoQDhAiVWX4JZjj-5BiROfhYuabj3gTXJk4nwtkhpAlvZaKN7ZU37T4VPCiZrDe7pFE8DF6FMWqHdp90yushmAibNlJxTMNt0jip7DW40NwGdXN8F-D9eb1bvabbt5fN6mmb1hjTPiV1rcusKmBGJKVQiirXhFJBiUCykFLlQmOYoRpBjDnhWuCqLklJMaS44govwP3U23n3OajQs8aEWlnLW-WGwLIMFqiAOKtiFE7R2rsQvNKs8_Fg_8UQZKNRNupjoz42GY3I3bF9EI2SJ-BHYQzQX5216XkfnfSeG_tf88MEGtexgxt8Gy39Hf8GbL-PuQ</recordid><startdate>20190604</startdate><enddate>20190604</enddate><creator>Stowe, Symon</creator><creator>Boyle, Alistair</creator><creator>Sage, Michaël</creator><creator>See, Wendy</creator><creator>Praud, Jean-Paul</creator><creator>Fortin-Pellerin, Étienne</creator><creator>Adler, Andy</creator><general>IOP Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2312-5346</orcidid><orcidid>https://orcid.org/0000-0002-4453-1511</orcidid><orcidid>https://orcid.org/0000-0002-2738-2446</orcidid></search><sort><creationdate>20190604</creationdate><title>Comparison of bolus- and filtering-based EIT measures of lung perfusion in an animal model</title><author>Stowe, Symon ; Boyle, Alistair ; Sage, Michaël ; See, Wendy ; Praud, Jean-Paul ; Fortin-Pellerin, Étienne ; Adler, Andy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-4ccf8297024d660db95f466b64b1d7dde5bf3021c1033a4afb39c848630639ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Electric Impedance</topic><topic>electrical impedance tomography</topic><topic>Lung - physiology</topic><topic>lung perfusion</topic><topic>Models, Animal</topic><topic>Perfusion</topic><topic>Sheep</topic><topic>Tomography</topic><topic>ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stowe, Symon</creatorcontrib><creatorcontrib>Boyle, Alistair</creatorcontrib><creatorcontrib>Sage, Michaël</creatorcontrib><creatorcontrib>See, Wendy</creatorcontrib><creatorcontrib>Praud, Jean-Paul</creatorcontrib><creatorcontrib>Fortin-Pellerin, Étienne</creatorcontrib><creatorcontrib>Adler, Andy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physiological measurement</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stowe, Symon</au><au>Boyle, Alistair</au><au>Sage, Michaël</au><au>See, Wendy</au><au>Praud, Jean-Paul</au><au>Fortin-Pellerin, Étienne</au><au>Adler, Andy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of bolus- and filtering-based EIT measures of lung perfusion in an animal model</atitle><jtitle>Physiological measurement</jtitle><stitle>PM</stitle><addtitle>Physiol. Meas</addtitle><date>2019-06-04</date><risdate>2019</risdate><volume>40</volume><issue>5</issue><spage>054002</spage><epage>054002</epage><pages>054002-054002</pages><issn>0967-3334</issn><issn>1361-6579</issn><eissn>1361-6579</eissn><coden>PMEAE3</coden><abstract>Objective: Two main functional imaging approaches have been used to measure regional lung perfusion using electrical impedance tomography (EIT): venous injection of a hypertonic saline contrast agent and imaging of its passage through the heart and lungs, and digital filtering of heart-frequency impedance changes over sequences of EIT images. This paper systematically compares filtering-based perfusion estimates and bolus injection methods to determine to which degree they are related. Approach: EIT data was recorded on seven mechanically ventilated newborn lambs in which ventilation distribution was varied through changes in posture between prone, supine, left- and right-lateral positions. Perfusion images were calculated using frequency filtering and ensemble averaging during both ventilation and apnoea time segments for each posture to compare against contrast agent-based methods using Jaccard distance score. Main results: Using bolus-based EIT measures of lung perfusion as the reference frequency filtering techniques performed better than ensemble averaging and both techniques performed equally well across apnoea and ventilation data segments. Significance: Our results indicate the potential for use of filtering-based EIT measures of heart-frequency activity as a non-invasive proxy for contrast agent injection-based measures of lung perfusion.</abstract><cop>England</cop><pub>IOP Publishing</pub><pmid>30965314</pmid><doi>10.1088/1361-6579/ab1794</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2312-5346</orcidid><orcidid>https://orcid.org/0000-0002-4453-1511</orcidid><orcidid>https://orcid.org/0000-0002-2738-2446</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0967-3334
ispartof Physiological measurement, 2019-06, Vol.40 (5), p.054002-054002
issn 0967-3334
1361-6579
1361-6579
language eng
recordid cdi_crossref_primary_10_1088_1361_6579_ab1794
source MEDLINE; HEAL-Link subscriptions: Institute of Physics (IOP) Journals; Institute of Physics Journals
subjects Animals
Electric Impedance
electrical impedance tomography
Lung - physiology
lung perfusion
Models, Animal
Perfusion
Sheep
Tomography
ventilation
title Comparison of bolus- and filtering-based EIT measures of lung perfusion in an animal model
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T08%3A26%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20bolus-%20and%20filtering-based%20EIT%20measures%20of%20lung%20perfusion%20in%20an%20animal%20model&rft.jtitle=Physiological%20measurement&rft.au=Stowe,%20Symon&rft.date=2019-06-04&rft.volume=40&rft.issue=5&rft.spage=054002&rft.epage=054002&rft.pages=054002-054002&rft.issn=0967-3334&rft.eissn=1361-6579&rft.coden=PMEAE3&rft_id=info:doi/10.1088/1361-6579/ab1794&rft_dat=%3Cproquest_cross%3E2207170329%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2207170329&rft_id=info:pmid/30965314&rfr_iscdi=true