Recurrent, Multifocal Mycobacterium avium-intercellulare Infection in a Patient with Interferon-γ Autoantibody

We describe a patient who experienced severe osteomyelitis because of Mycobacterium avium-intercellulare infection and high-titered autoantibodies against interferon-γ. In addition to antimycobacterial chemotherapy, we treated our patient with plasmapheresis and cyclophosphamide. The treatment induc...

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Veröffentlicht in:	Clinical infectious diseases 2009-10, Vol.49 (7), p.e76-e78
Hauptverfasser:	Baerlecken, N., Jacobs, R., Stoll, M., Schmidt, R. E., Witte, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antitubercular Agents - therapeutic use Autoantibodies - blood Autoimmune Diseases - complications Cyclophosphamide - therapeutic use Female Humans Immunosuppressive Agents - therapeutic use Interferon-gamma - immunology Mycobacterium avium - isolation & purification Mycobacterium Infections - drug therapy Mycobacterium Infections - microbiology Mycobacterium Infections - therapy Osteomyelitis - microbiology Plasmapheresis Recurrence
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Beschreibung
Zusammenfassung:	We describe a patient who experienced severe osteomyelitis because of Mycobacterium avium-intercellulare infection and high-titered autoantibodies against interferon-γ. In addition to antimycobacterial chemotherapy, we treated our patient with plasmapheresis and cyclophosphamide. The treatment induced a remission after 3 years of follow-up.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/605581