Severe Postvaccinia Encephalitis with Acute Disseminated Encephalomyelitis: Recovery with Early Intravenous Immunoglobulin, High-Dose Steroids, and Vaccinia Immunoglobulin

We report the second case of severe postvaccinial encephalitis with acute disseminated encephalomyelitis since smallpox vaccination was reintroduced in 2002. Both affected patients responded dramatically with early intervention of intravenous immunoglobulin. Our patient, who also received concurrent...

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Veröffentlicht in:	Clinical infectious diseases 2009-02, Vol.48 (4), p.e47-e49
Hauptverfasser:	Van Dam, Cornelius N., Syed, Samina, Eron, Joseph J., Ostrander, Matthew, Engler, Renata J. M., Damon, Inger, Montgomery, Jay R., Tong, Suxiang, Adimora, Adaora A., Kahn, Kevin A., Ruone, Susan, Anderson, Larry, Weber, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Encephalomyelitis, Acute Disseminated - chemically induced Encephalomyelitis, Acute Disseminated - drug therapy Humans Immunoglobulins, Intravenous - therapeutic use Immunologic Factors - therapeutic use Male Smallpox Vaccine - adverse effects Steroids - therapeutic use Treatment Outcome Vaccinia - complications Vaccinia - drug therapy Young Adult
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Zusammenfassung:	We report the second case of severe postvaccinial encephalitis with acute disseminated encephalomyelitis since smallpox vaccination was reintroduced in 2002. Both affected patients responded dramatically with early intervention of intravenous immunoglobulin. Our patient, who also received concurrent vaccinia immunoglobulin and corticosteroids, demonstrated full recovery.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/596553