Cytomegalovirus Infection in Transplant Recipients Resolves When Circulating γδ T Lymphocytes Expand, Suggesting a Protective Antiviral Role

γδ T cells undergo massive expansion in the peripheral blood of renal transplant recipients who are infected with cytomegalovirus (CMV). In a 3-year prospective study, the relationship between the evolution of CMV infection and the kinetics of γδ T cell amplification was followed for 10 months after...

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Veröffentlicht in:The Journal of infectious diseases 2001-09, Vol.184 (5), p.533-541
Hauptverfasser: Lafarge, Xavier, Merville, Pierre, Cazin, Marie-Cécile, Bergé, Frank, Potaux, Luc, Moreau, Jean-François, Déchanet-Merville, Julie
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Sprache:eng
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Zusammenfassung:γδ T cells undergo massive expansion in the peripheral blood of renal transplant recipients who are infected with cytomegalovirus (CMV). In a 3-year prospective study, the relationship between the evolution of CMV infection and the kinetics of γδ T cell amplification was followed for 10 months after transplantation. Patients with late γδ T cell expansion (⩾45 days) had significantly longer (P
ISSN:0022-1899
1537-6613
DOI:10.1086/322843