Human KIT+ myeloid cells facilitate visceral metastasis by melanoma

Metastasis of melanoma significantly worsens prognosis; thus, therapeutic interventions that prevent metastasis could improve patient outcomes. Here, we show using humanized mice that colonization of distant visceral organs with melanoma is dependent upon a human CD33+CD11b+CD117+ progenitor cell su...

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Veröffentlicht in:	The Journal of experimental medicine 2021-06, Vol.218 (6), Article 20182163
Hauptverfasser:	Yu, Chun I., Martinek, Jan, Wu, Te-Chia, Kim, Kyung In, George, Joshy, Ahmadzadeh, Elaheh, Maser, Rick, Marches, Florentina, Metang, Patrick, Authie, Pierre, Oliveira, Vanessa K. P., Wang, Victor G., Chuang, Jeffrey H., Robson, Paul, Banchereau, Jacques, Palucka, Karolina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - metabolism Brief Definitive Report CD11b Antigen - metabolism Cell Line, Tumor Cohort Studies Humans Immunology Innate Immunity and Inflammation Leukocyte Common Antigens - metabolism Leukocytes - metabolism Leukocytes - pathology Life Sciences & Biomedicine Medicine, Research & Experimental Melanoma - metabolism Melanoma - pathology Mice Mice, Inbred NOD Myeloid Cells - metabolism Myeloid Cells - pathology Prognosis Proto-Oncogene Proteins c-kit - metabolism Research & Experimental Medicine Science & Technology Tumor Immunology
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Zusammenfassung:	Metastasis of melanoma significantly worsens prognosis; thus, therapeutic interventions that prevent metastasis could improve patient outcomes. Here, we show using humanized mice that colonization of distant visceral organs with melanoma is dependent upon a human CD33+CD11b+CD117+ progenitor cell subset comprising
ISSN:	0022-1007 1540-9538
DOI:	10.1084/jem.20182163