Dolutegravir-based regimens in treatment-naive and treatment-experienced aging populations: analyses of 6 phase III clinical trials

Dolutegravir-based regimens in treatment-naive and treatment-experienced aging populations: analyses of 6 phase III clinical trials

Background: Older adults living with HIV (OALWH) are a growing population facing unique challenges to successful antiretroviral therapy. Objective: To assess efficacy and safety profiles of antiretroviral regimens, including those containing dolutegravir, in OALWH. Methods: Combined data from 6 phas...

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Veröffentlicht in:HIV research & clinical practice 2021-07, Vol.22 (2), p.46-54
Hauptverfasser: Spinelli, Frank, Prakash, Manyu, Slater, Jill, van der Kolk, Mike, Bassani, Niccolò, Grove, Richard, Wynne, Brian, van Wyk, Jean, Clark, Andrew
Format: Artikel
Sprache:eng
Schlagworte:
antiretroviral therapy
comorbidities
integrase strand transfer inhibitor
older adults living with HIV
polypharmacy
virologic suppression
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Zusammenfassung:Background: Older adults living with HIV (OALWH) are a growing population facing unique challenges to successful antiretroviral therapy. Objective: To assess efficacy and safety profiles of antiretroviral regimens, including those containing dolutegravir, in OALWH. Methods: Combined data from 6 phase III/IIIb trials in treatment-naive (ARIA, FLAMINGO, SINGLE, SPRING-2; N = 2634) and treatment-experienced (DAWNING, SAILING; N = 1339) participants receiving dolutegravir- or non-dolutegravir-based regimens were analyzed by age (
ISSN:2578-7489
2578-7470
DOI:10.1080/25787489.2021.1941672