Yes, MAM
Regulation of cell life and death by members of the BCL-2 family of proteins occurs at the mitochondria. Large portions of the mitochondria's outer membrane are found in tight approximation with the endoplasmic reticulum (ER), known as mitochondria-associated membranes (MAMs) or mitochondria-ER...
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Veröffentlicht in: | Molecular & cellular oncology 2021-07, Vol.8 (4), p.1919473-1919473 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Regulation of cell life and death by members of the BCL-2 family of proteins occurs at the mitochondria. Large portions of the mitochondria's outer membrane are found in tight approximation with the endoplasmic reticulum (ER), known as mitochondria-associated membranes (MAMs) or mitochondria-ER contact sites (MERCs). We recently reported that BOK is present within MAMs where it regulates Ca
2+
transfer from the ER to the mitochondria, appropriate MAM components and MERC structure, and apoptosis. |
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ISSN: | 2372-3556 2372-3556 |
DOI: | 10.1080/23723556.2021.1919473 |