The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth

The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth

The macroH2A1.2 histone variant facilitates the response to replication stress with implications for genome maintenance and cell growth. A mutually exclusive splice variant, macroH2A1.1, has opposing effects on DNA repair outcome and proliferation. Here we discuss the potential impact of splicing-mo...

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Veröffentlicht in:Molecular & cellular oncology 2018-05, Vol.5 (3), p.e1441629-e1441629
Hauptverfasser: Kim, Jeongkyu, Oberdoerffer, Philipp, Khurana, Simran
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creator Kim, Jeongkyu
Oberdoerffer, Philipp
Khurana, Simran
description The macroH2A1.2 histone variant facilitates the response to replication stress with implications for genome maintenance and cell growth. A mutually exclusive splice variant, macroH2A1.1, has opposing effects on DNA repair outcome and proliferation. Here we discuss the potential impact of splicing-modulated macroH2A1 chromatin organization for cell function and malignant transformation.
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title The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth
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