The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth

The macroH2A1.2 histone variant facilitates the response to replication stress with implications for genome maintenance and cell growth. A mutually exclusive splice variant, macroH2A1.1, has opposing effects on DNA repair outcome and proliferation. Here we discuss the potential impact of splicing-mo...

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Veröffentlicht in:	Molecular & cellular oncology 2018-05, Vol.5 (3), p.e1441629-e1441629
Hauptverfasser:	Kim, Jeongkyu, Oberdoerffer, Philipp, Khurana, Simran
Format:	Artikel
Sprache:	eng
Schlagworte:	Author's Views
Online-Zugang:	Volltext
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Zusammenfassung:	The macroH2A1.2 histone variant facilitates the response to replication stress with implications for genome maintenance and cell growth. A mutually exclusive splice variant, macroH2A1.1, has opposing effects on DNA repair outcome and proliferation. Here we discuss the potential impact of splicing-modulated macroH2A1 chromatin organization for cell function and malignant transformation.
ISSN:	2372-3556 2372-3556
DOI:	10.1080/23723556.2018.1441629