Electrochemical determination of paracetamol, rutin and sulfonamide in pharmaceutical formulations by using glassy carbon electrode - A Review

Recent advances in the electrochemical application of glassy carbon electrode for determination of selected drugs in pharmaceutical formulations are reviewed. Several analytical techniques such as liquid chromatography, high performance liquid chromatography, spectrophotometry, chemiluminescence, and capillary electrophoresis-mass spectrometry have been used for the detection and separation of pharmaceutical active components due to their high sensitivity and great selectivity. However, all these methods are complicated, time-consuming and require expensive equipment. In contrast to these conventional techniques, the electrochemical technique overcomes those drawbacks owing to its low cost, rapid response and application in on-site test. Special attention is paid on this review for electrochemical application of bare and modified glassy carbon electrode for the determination of paracetamol, rutin and sulfonamide in pharmaceutical formulation.