Heterobimetallic complexes containing Sn(IV) and Pd(II) with 4-(2-Hydroxyethyl)piperazine-1-carbodithioic acid: Synthesis, characterization and biological activities
Four heterobimetallic derivatives of the type, [R 2 (Cl)SnL]PdCl 2 (R = n-Bu: 1)/[R 3 SnL]PdCl 2 (R = Me: 2; n-Bu: 3; Ph: 4) where L = 4-(2-hydroxyethyl)piperazine-1-carbodithioic acid, have been synthesized by refluxing 4-(2-hydroxyethyl)piperazine-1-carbodithioic acid with R 2 SnCl 2 /R 3 SnCl in...
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| Veröffentlicht in: | Cogent chemistry 2015-12, Vol.1 (1), p.1029038 |
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| creator | Hussain, Shabbir Ali, Saqib Shahzadi, Saira Shahid, Muhammad |
| description | Four heterobimetallic derivatives of the type, [R
2
(Cl)SnL]PdCl
2
(R = n-Bu: 1)/[R
3
SnL]PdCl
2
(R = Me: 2; n-Bu: 3; Ph: 4) where L = 4-(2-hydroxyethyl)piperazine-1-carbodithioic acid, have been synthesized by refluxing 4-(2-hydroxyethyl)piperazine-1-carbodithioic acid with R
2
SnCl
2
/R
3
SnCl in 1:1 M/L ratio and then stirring with PdCl
2
at room temperature. The complexes have been characterized by various spectroscopic (IR,
1
H and
13
C NMR, and EI-MS) techniques and thermogravimetric analysis. FTIR data demonstrated the bidentate binding of dithiocarbamate group. The NMR data demonstrated 4-coordinated geometry in solution. The complex 4 exhibits the interaction with salmon sperm DNA (SS-DNA) with significant hypochromic effect and suggests intercalating mode of binding. The complex 2 was found most active for inhibition of alkaline phosphates enzyme (ALPs). The complexes 1-4 showed significant antimicrobial activities as compared to the inactive free ligand precursor. The in vitro hemolytic activity showed that average lysis of human red blood cells was significantly lower as compared to Triton-X 100 (positive control, 100% lysis). |
| doi_str_mv | 10.1080/23312009.2015.1029038 |
| format | Article |
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2
(Cl)SnL]PdCl
2
(R = n-Bu: 1)/[R
3
SnL]PdCl
2
(R = Me: 2; n-Bu: 3; Ph: 4) where L = 4-(2-hydroxyethyl)piperazine-1-carbodithioic acid, have been synthesized by refluxing 4-(2-hydroxyethyl)piperazine-1-carbodithioic acid with R
2
SnCl
2
/R
3
SnCl in 1:1 M/L ratio and then stirring with PdCl
2
at room temperature. The complexes have been characterized by various spectroscopic (IR,
1
H and
13
C NMR, and EI-MS) techniques and thermogravimetric analysis. FTIR data demonstrated the bidentate binding of dithiocarbamate group. The NMR data demonstrated 4-coordinated geometry in solution. The complex 4 exhibits the interaction with salmon sperm DNA (SS-DNA) with significant hypochromic effect and suggests intercalating mode of binding. The complex 2 was found most active for inhibition of alkaline phosphates enzyme (ALPs). The complexes 1-4 showed significant antimicrobial activities as compared to the inactive free ligand precursor. The in vitro hemolytic activity showed that average lysis of human red blood cells was significantly lower as compared to Triton-X 100 (positive control, 100% lysis).</description><identifier>ISSN: 2331-2009</identifier><identifier>EISSN: 2331-2009</identifier><identifier>DOI: 10.1080/23312009.2015.1029038</identifier><language>eng</language><publisher>Abingdon: Cogent</publisher><subject>4-(2-Hydroxyethyl)piperazine-1-carbodithioic acid ; Antiinfectives and antibacterials ; Binding ; biological activities ; DNA interaction ; Erythrocytes ; NMR ; Nuclear magnetic resonance ; Pd(II) ; Phosphates ; Refluxing ; Room temperature ; Salmon ; Sn(IV) ; spectroscopy ; thermal ; Thermogravimetric analysis</subject><ispartof>Cogent chemistry, 2015-12, Vol.1 (1), p.1029038</ispartof><rights>2015 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license 2015</rights><rights>2015 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-cb7cfe0a07dbbc2d9ee61fcdf721404e30e328d8710c84aef19014c24feb782c3</citedby><cites>FETCH-LOGICAL-c315t-cb7cfe0a07dbbc2d9ee61fcdf721404e30e328d8710c84aef19014c24feb782c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/23312009.2015.1029038$$EPDF$$P50$$Ginformaworld$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/23312009.2015.1029038$$EHTML$$P50$$Ginformaworld$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27479,27901,27902,59116,59117</link.rule.ids></links><search><contributor>Slawin, Alexandra</contributor><creatorcontrib>Hussain, Shabbir</creatorcontrib><creatorcontrib>Ali, Saqib</creatorcontrib><creatorcontrib>Shahzadi, Saira</creatorcontrib><creatorcontrib>Shahid, Muhammad</creatorcontrib><title>Heterobimetallic complexes containing Sn(IV) and Pd(II) with 4-(2-Hydroxyethyl)piperazine-1-carbodithioic acid: Synthesis, characterization and biological activities</title><title>Cogent chemistry</title><description>Four heterobimetallic derivatives of the type, [R
2
(Cl)SnL]PdCl
2
(R = n-Bu: 1)/[R
3
SnL]PdCl
2
(R = Me: 2; n-Bu: 3; Ph: 4) where L = 4-(2-hydroxyethyl)piperazine-1-carbodithioic acid, have been synthesized by refluxing 4-(2-hydroxyethyl)piperazine-1-carbodithioic acid with R
2
SnCl
2
/R
3
SnCl in 1:1 M/L ratio and then stirring with PdCl
2
at room temperature. The complexes have been characterized by various spectroscopic (IR,
1
H and
13
C NMR, and EI-MS) techniques and thermogravimetric analysis. FTIR data demonstrated the bidentate binding of dithiocarbamate group. The NMR data demonstrated 4-coordinated geometry in solution. The complex 4 exhibits the interaction with salmon sperm DNA (SS-DNA) with significant hypochromic effect and suggests intercalating mode of binding. The complex 2 was found most active for inhibition of alkaline phosphates enzyme (ALPs). The complexes 1-4 showed significant antimicrobial activities as compared to the inactive free ligand precursor. The in vitro hemolytic activity showed that average lysis of human red blood cells was significantly lower as compared to Triton-X 100 (positive control, 100% lysis).</description><subject>4-(2-Hydroxyethyl)piperazine-1-carbodithioic acid</subject><subject>Antiinfectives and antibacterials</subject><subject>Binding</subject><subject>biological activities</subject><subject>DNA interaction</subject><subject>Erythrocytes</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Pd(II)</subject><subject>Phosphates</subject><subject>Refluxing</subject><subject>Room temperature</subject><subject>Salmon</subject><subject>Sn(IV)</subject><subject>spectroscopy</subject><subject>thermal</subject><subject>Thermogravimetric analysis</subject><issn>2331-2009</issn><issn>2331-2009</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>BENPR</sourceid><recordid>eNp9UdtqGzEQXUoCDWk-obDQFxuyqS5ra92nlpDWhkACSfsqtNIoniBLW0m5bP6n_xk5TiFPeZrDzLnAnKr6TMkJJR35yjinjJDFCSN0VlZsQXj3oTrY7pvtYe8N_lgdpXRLCKGtIGIuDqp_S8gQQ48byMo51LUOm8HBI6SCfFbo0d_UV36y-jOtlTf1pZmsVtP6AfO6bpsJa5ajieFxhLwe3XTAAaJ6Qg8NbbSKfTCFiKEYK43mW301-ryGhOm41msVlS7x-KQyBv9i32Nw4Qa1ckWQ8R4zQvpU7VvlEhy9zsPq98-z69Nlc37xa3X647zRnM5yo3uhLRBFhOl7zcwCYE6tNlYw2pIWOAHOOtMJSnTXKrB0UT6hWWuhFx3T_LD6svMdYvh7BynL23AXfYmUtOOCcSH4vLBmO5aOIaUIVg4RNyqOkhK5LUX-L0VuS5GvpRTd950OvQ1xox5CdEZmNboQbVReY5L8fYtniHuVzg</recordid><startdate>20151231</startdate><enddate>20151231</enddate><creator>Hussain, Shabbir</creator><creator>Ali, Saqib</creator><creator>Shahzadi, Saira</creator><creator>Shahid, Muhammad</creator><general>Cogent</general><general>Taylor & Francis Ltd</general><scope>0YH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20151231</creationdate><title>Heterobimetallic complexes containing Sn(IV) and Pd(II) with 4-(2-Hydroxyethyl)piperazine-1-carbodithioic acid: Synthesis, characterization and biological activities</title><author>Hussain, Shabbir ; Ali, Saqib ; Shahzadi, Saira ; Shahid, Muhammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-cb7cfe0a07dbbc2d9ee61fcdf721404e30e328d8710c84aef19014c24feb782c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>4-(2-Hydroxyethyl)piperazine-1-carbodithioic acid</topic><topic>Antiinfectives and antibacterials</topic><topic>Binding</topic><topic>biological activities</topic><topic>DNA interaction</topic><topic>Erythrocytes</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Pd(II)</topic><topic>Phosphates</topic><topic>Refluxing</topic><topic>Room temperature</topic><topic>Salmon</topic><topic>Sn(IV)</topic><topic>spectroscopy</topic><topic>thermal</topic><topic>Thermogravimetric analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hussain, Shabbir</creatorcontrib><creatorcontrib>Ali, Saqib</creatorcontrib><creatorcontrib>Shahzadi, Saira</creatorcontrib><creatorcontrib>Shahid, Muhammad</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Cogent chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hussain, Shabbir</au><au>Ali, Saqib</au><au>Shahzadi, Saira</au><au>Shahid, Muhammad</au><au>Slawin, Alexandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heterobimetallic complexes containing Sn(IV) and Pd(II) with 4-(2-Hydroxyethyl)piperazine-1-carbodithioic acid: Synthesis, characterization and biological activities</atitle><jtitle>Cogent chemistry</jtitle><date>2015-12-31</date><risdate>2015</risdate><volume>1</volume><issue>1</issue><spage>1029038</spage><pages>1029038-</pages><issn>2331-2009</issn><eissn>2331-2009</eissn><abstract>Four heterobimetallic derivatives of the type, [R
2
(Cl)SnL]PdCl
2
(R = n-Bu: 1)/[R
3
SnL]PdCl
2
(R = Me: 2; n-Bu: 3; Ph: 4) where L = 4-(2-hydroxyethyl)piperazine-1-carbodithioic acid, have been synthesized by refluxing 4-(2-hydroxyethyl)piperazine-1-carbodithioic acid with R
2
SnCl
2
/R
3
SnCl in 1:1 M/L ratio and then stirring with PdCl
2
at room temperature. The complexes have been characterized by various spectroscopic (IR,
1
H and
13
C NMR, and EI-MS) techniques and thermogravimetric analysis. FTIR data demonstrated the bidentate binding of dithiocarbamate group. The NMR data demonstrated 4-coordinated geometry in solution. The complex 4 exhibits the interaction with salmon sperm DNA (SS-DNA) with significant hypochromic effect and suggests intercalating mode of binding. The complex 2 was found most active for inhibition of alkaline phosphates enzyme (ALPs). The complexes 1-4 showed significant antimicrobial activities as compared to the inactive free ligand precursor. The in vitro hemolytic activity showed that average lysis of human red blood cells was significantly lower as compared to Triton-X 100 (positive control, 100% lysis).</abstract><cop>Abingdon</cop><pub>Cogent</pub><doi>10.1080/23312009.2015.1029038</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2331-2009 |
| ispartof | Cogent chemistry, 2015-12, Vol.1 (1), p.1029038 |
| issn | 2331-2009 2331-2009 |
| language | eng |
| recordid | cdi_crossref_primary_10_1080_23312009_2015_1029038 |
| source | Taylor & Francis Open Access; EZB-FREE-00999 freely available EZB journals |
| subjects | 4-(2-Hydroxyethyl)piperazine-1-carbodithioic acid Antiinfectives and antibacterials Binding biological activities DNA interaction Erythrocytes NMR Nuclear magnetic resonance Pd(II) Phosphates Refluxing Room temperature Salmon Sn(IV) spectroscopy thermal Thermogravimetric analysis |
| title | Heterobimetallic complexes containing Sn(IV) and Pd(II) with 4-(2-Hydroxyethyl)piperazine-1-carbodithioic acid: Synthesis, characterization and biological activities |
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