Heterobimetallic complexes containing Sn(IV) and Pd(II) with 4-(2-Hydroxyethyl)piperazine-1-carbodithioic acid: Synthesis, characterization and biological activities

Four heterobimetallic derivatives of the type, [R 2 (Cl)SnL]PdCl 2 (R = n-Bu: 1)/[R 3 SnL]PdCl 2 (R = Me: 2; n-Bu: 3; Ph: 4) where L = 4-(2-hydroxyethyl)piperazine-1-carbodithioic acid, have been synthesized by refluxing 4-(2-hydroxyethyl)piperazine-1-carbodithioic acid with R 2 SnCl 2 /R 3 SnCl in 1:1 M/L ratio and then stirring with PdCl 2 at room temperature. The complexes have been characterized by various spectroscopic (IR, 1 H and 13 C NMR, and EI-MS) techniques and thermogravimetric analysis. FTIR data demonstrated the bidentate binding of dithiocarbamate group. The NMR data demonstrated 4-coordinated geometry in solution. The complex 4 exhibits the interaction with salmon sperm DNA (SS-DNA) with significant hypochromic effect and suggests intercalating mode of binding. The complex 2 was found most active for inhibition of alkaline phosphates enzyme (ALPs). The complexes 1-4 showed significant antimicrobial activities as compared to the inactive free ligand precursor. The in vitro hemolytic activity showed that average lysis of human red blood cells was significantly lower as compared to Triton-X 100 (positive control, 100% lysis).