Improved antibacterial function of Rifampicin-loaded solid lipid nanoparticles on Brucella abortus

The objective of this study was to assess the antibacterial activity of Rifampicin-loaded solid lipid nanoparticles on Brucella abortus 544. Rifampicin-loaded solid lipid nanoparticles were prepared by a modified microemulsion/sonication method and characterized. The results showed the average size...

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Veröffentlicht in:	Artificial cells, nanomedicine, and biotechnology nanomedicine, and biotechnology, 2019-12, Vol.47 (1), p.1181-1193
Hauptverfasser:	Ghaderkhani, Jalal, Yousefimashouf, Rasoul, Arabestani, Mohammadreza, Roshanaei, Ghodratollah, Asl, Sara Soleimani, Abbasalipourkabir, Roghayeh
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial activity Brucella abortus Cell culture Culture media Drug delivery systems Lipids Nanoparticles rifampicin Rifampin Solid lipid nanoparticles Sonication Statistical analysis Zeta potential
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Zusammenfassung:	The objective of this study was to assess the antibacterial activity of Rifampicin-loaded solid lipid nanoparticles on Brucella abortus 544. Rifampicin-loaded solid lipid nanoparticles were prepared by a modified microemulsion/sonication method and characterized. The results showed the average size about 319.7 nm, PI about 0.20 and zeta potential about 18.4 mv, encapsulation efficacy and drug-loading were equal to 95.78 and 34.2%, respectively, with a spherical shape. Drug release lasted for 5 days. The antibacterial activity was statistically significant with p
ISSN:	2169-1401 2169-141X
DOI:	10.1080/21691401.2019.1593858