"Suffocating" tumors by blocking adaptation to hypoxia: a new headway in melanoma immunotherapy

"Suffocating" tumors by blocking adaptation to hypoxia: a new headway in melanoma immunotherapy

We recently reported that inhibiting Hypoxia-inducible Factor-1α (Hif1a) transcriptional activity improves melanoma immunotherapy by driving immune cells into the tumor microenvironment (TME). This Author's View provides additional perspectives on how hypoxia inhibitors combined with immunother...

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Veröffentlicht in:Oncoimmunology 2021-01, Vol.10 (1), p.1968611-1968611
Hauptverfasser: Janji, Bassam, Chouaib, Salem
Format: Artikel
Sprache:eng
Schlagworte:
anti-PD-1/PD-L1
Author’s View
cancer immunotherapy
CCL5/Rantes
CD8 T-lymphocytes
chemokines
cold/hot tumors
Hypoxia
hypoxia-inducible factor
immune landscape
melanoma
NK cells
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Zusammenfassung:We recently reported that inhibiting Hypoxia-inducible Factor-1α (Hif1a) transcriptional activity improves melanoma immunotherapy by driving immune cells into the tumor microenvironment (TME). This Author's View provides additional perspectives on how hypoxia inhibitors combined with immunotherapy can be used as innovative approaches to improve the therapeutic benefit of melanoma patients.
ISSN:2162-402X
2162-4011
2162-402X
DOI:10.1080/2162402X.2021.1968611