The Beta-Adrenergic Receptor in Heart Failure

Although the role of the autonomic nervous system in the pathophysiology of heart failure has been studied for decades, only within the past few years have adrenergic receptors and their alterations occupied center stage. There is now considerable evidence linking such receptors to many of the pheno...

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Veröffentlicht in:Hospital practice (1995) 1983-11, Vol.18 (11), p.103-125
Hauptverfasser: Heinsimer, James A., Lefkowitz, Robert J.
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container_issue 11
container_start_page 103
container_title Hospital practice (1995)
container_volume 18
creator Heinsimer, James A.
Lefkowitz, Robert J.
description Although the role of the autonomic nervous system in the pathophysiology of heart failure has been studied for decades, only within the past few years have adrenergic receptors and their alterations occupied center stage. There is now considerable evidence linking such receptors to many of the phenomena of heart failure; recent work appears to have significant therapeutic implications.
doi_str_mv 10.1080/21548331.1983.11702685
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source MEDLINE; Taylor & Francis:Master (3349 titles)
subjects Adrenergic beta-Agonists - therapeutic use
Adrenergic beta-Antagonists - therapeutic use
Animals
Autonomic Nervous System - physiopathology
Binding Sites - drug effects
Catecholamines - metabolism
Heart - physiopathology
Heart Failure - drug therapy
Heart Failure - physiopathology
Humans
Ligands
Models, Biological
Myocardium - metabolism
Norepinephrine - physiology
Protein Binding - drug effects
Receptors, Adrenergic, alpha - analysis
Receptors, Adrenergic, alpha - drug effects
Receptors, Adrenergic, alpha - physiology
Receptors, Adrenergic, beta - analysis
Receptors, Adrenergic, beta - drug effects
Receptors, Adrenergic, beta - physiology
title The Beta-Adrenergic Receptor in Heart Failure
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