Gut microbiome signatures reflect different subtypes of irritable bowel syndrome

Gut microbiome signatures reflect different subtypes of irritable bowel syndrome

Irritable bowel syndrome (IBS) is a heterogeneous condition with multifactorial pathogenesis. We studied deeply phenotyped individuals with microbiota sequencing enrolled in the American Gut Project. The IBS subjects were matched by age, gender, body mass index, geography, and dietary patterns with...

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Veröffentlicht in:Gut microbes 2023-12, Vol.15 (1), p.2157697-2157697
Hauptverfasser: Su, Qi, Tun, Hein M, Liu, Qin, Yeoh, Yun Kit, Mak, Joyce Wing Yan, Chan, Francis KL, Ng, Siew C
Format: Artikel
Sprache:eng
Schlagworte:
Bacteria - genetics
Constipation - complications
depression
Diarrhea - microbiology
diet
Dysbiosis - microbiology
Feces - microbiology
Female
Gastrointestinal Microbiome
gut microbiome
Humans
Irritable bowel syndrome
Irritable Bowel Syndrome - microbiology
Research Paper
subtype
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Zusammenfassung:Irritable bowel syndrome (IBS) is a heterogeneous condition with multifactorial pathogenesis. We studied deeply phenotyped individuals with microbiota sequencing enrolled in the American Gut Project. The IBS subjects were matched by age, gender, body mass index, geography, and dietary patterns with non-IBS controls. A total of 942 subjects with IBS-Diarrhea (IBS-D), IBS-Constipation (IBS-C), unclassified IBS (IBS-U), and 942 non-IBS controls were included. We compared taxonomic and functional composition of gut microbiota based on 16S sequencing data and linked them with clinical characteristics and dietary factors. Subjects with IBS-D or IBS-U but not IBS-C showed significantly reduced bacterial diversity (Shannon; p
ISSN:1949-0976
1949-0984
DOI:10.1080/19490976.2022.2157697