Virulence-related O islands in enterohemorrhagic Escherichia coli O157:H7
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a principally foodborne pathogen linked to serious diseases, including bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome. Comparative genomics analysis revealed that EHEC O157 contains 177 unique genomic islands, termed O islands...
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| Veröffentlicht in: | Gut microbes 2021-01, Vol.13 (1), p.1992237-1992237 |
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| creator | Jiang, Lingyan Yang, Wen Jiang, Xinlei Yao, Ting Wang, Lu Yang, Bin |
| description | Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a principally foodborne pathogen linked to serious diseases, including bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome. Comparative genomics analysis revealed that EHEC O157 contains 177 unique genomic islands, termed O islands, compared with the nonpathogenic E. coli K-12 laboratory strain. These O islands contribute largely to the pathogenicity of EHEC O157:H7 by providing numerous virulence factors, effectors, virulence regulatory proteins, and virulence regulatory sRNAs. The present review aimed to provide a comprehensive understanding of the research progress on the function of O islands, especially focusing on virulence-related O islands. |
| doi_str_mv | 10.1080/19490976.2021.1992237 |
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Comparative genomics analysis revealed that EHEC O157 contains 177 unique genomic islands, termed O islands, compared with the nonpathogenic E. coli K-12 laboratory strain. These O islands contribute largely to the pathogenicity of EHEC O157:H7 by providing numerous virulence factors, effectors, virulence regulatory proteins, and virulence regulatory sRNAs. The present review aimed to provide a comprehensive understanding of the research progress on the function of O islands, especially focusing on virulence-related O islands.</description><identifier>ISSN: 1949-0976</identifier><identifier>EISSN: 1949-0984</identifier><identifier>DOI: 10.1080/19490976.2021.1992237</identifier><identifier>PMID: 34711138</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>adherence ; Animals ; Enterohemorrhagic Escherichia coli O157:H7 ; Escherichia coli Infections - microbiology ; Escherichia coli O157 - genetics ; Escherichia coli O157 - metabolism ; Escherichia coli O157 - pathogenicity ; Escherichia coli Proteins - genetics ; Escherichia coli Proteins - metabolism ; genomic island ; Genomic Islands ; Humans ; O island ; Review ; Virulence ; Virulence Factors - genetics ; Virulence Factors - metabolism</subject><ispartof>Gut microbes, 2021-01, Vol.13 (1), p.1992237-1992237</ispartof><rights>2021 The Author(s). 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The present review aimed to provide a comprehensive understanding of the research progress on the function of O islands, especially focusing on virulence-related O islands.</description><subject>adherence</subject><subject>Animals</subject><subject>Enterohemorrhagic Escherichia coli O157:H7</subject><subject>Escherichia coli Infections - microbiology</subject><subject>Escherichia coli O157 - genetics</subject><subject>Escherichia coli O157 - metabolism</subject><subject>Escherichia coli O157 - pathogenicity</subject><subject>Escherichia coli Proteins - genetics</subject><subject>Escherichia coli Proteins - metabolism</subject><subject>genomic island</subject><subject>Genomic Islands</subject><subject>Humans</subject><subject>O island</subject><subject>Review</subject><subject>Virulence</subject><subject>Virulence Factors - genetics</subject><subject>Virulence Factors - metabolism</subject><issn>1949-0976</issn><issn>1949-0984</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNp9kc1u1DAUhSMEolXpI4CyZJPB_3ZYIFBV6EiVZgNsLce-nrhy4mJnivr2eJjpiG7wxtbxud-99mmatxitMFLoA-5Zj3opVgQRvMJ9TwiVL5rzvd6hXrGXp7MUZ81lKXeoLsYkEvR1c0aZxBhTdd6sf4a8izBb6DJEs4BrN20o0cyutGFuYV4gpxGmlPNotsG218WOkIMdg2ltiqHdYC4_3sg3zStvYoHL437R_Ph6_f3qprvdfFtffbntLKds6axnWNU5iKWCcwOyJ9hUiUiEBSiQxktMBPdqwMibQQHz1ionBCJqII5eNOsD1yVzp-9zmEx-1MkE_VdIeatNXoKNoD1HFBCnkjvHOHED5eBBccqlEtLJyvp0YN3vhgmcra_NJj6DPr-Zw6i36UErLrgiqALeHwE5_dpBWfQUioVY_w_SrmjCe4QRoQxXKz9YbU6lZPCnNhjpfar6KVW9T1UfU6117_6d8VT1lGE1fD4YwuxTnszvlKPTi3mMKftsZhuKpv_v8QdKl6_i</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Jiang, Lingyan</creator><creator>Yang, Wen</creator><creator>Jiang, Xinlei</creator><creator>Yao, Ting</creator><creator>Wang, Lu</creator><creator>Yang, Bin</creator><general>Taylor & Francis</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20210101</creationdate><title>Virulence-related O islands in enterohemorrhagic Escherichia coli O157:H7</title><author>Jiang, Lingyan ; 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| subjects | adherence Animals Enterohemorrhagic Escherichia coli O157:H7 Escherichia coli Infections - microbiology Escherichia coli O157 - genetics Escherichia coli O157 - metabolism Escherichia coli O157 - pathogenicity Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism genomic island Genomic Islands Humans O island Review Virulence Virulence Factors - genetics Virulence Factors - metabolism |
| title | Virulence-related O islands in enterohemorrhagic Escherichia coli O157:H7 |
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