Virulence-related O islands in enterohemorrhagic Escherichia coli O157:H7

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a principally foodborne pathogen linked to serious diseases, including bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome. Comparative genomics analysis revealed that EHEC O157 contains 177 unique genomic islands, termed O islands...

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Veröffentlicht in:	Gut microbes 2021-01, Vol.13 (1), p.1992237-1992237
Hauptverfasser:	Jiang, Lingyan, Yang, Wen, Jiang, Xinlei, Yao, Ting, Wang, Lu, Yang, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	adherence Animals Enterohemorrhagic Escherichia coli O157:H7 Escherichia coli Infections - microbiology Escherichia coli O157 - genetics Escherichia coli O157 - metabolism Escherichia coli O157 - pathogenicity Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism genomic island Genomic Islands Humans O island Review Virulence Virulence Factors - genetics Virulence Factors - metabolism
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Zusammenfassung:	Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a principally foodborne pathogen linked to serious diseases, including bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome. Comparative genomics analysis revealed that EHEC O157 contains 177 unique genomic islands, termed O islands, compared with the nonpathogenic E. coli K-12 laboratory strain. These O islands contribute largely to the pathogenicity of EHEC O157:H7 by providing numerous virulence factors, effectors, virulence regulatory proteins, and virulence regulatory sRNAs. The present review aimed to provide a comprehensive understanding of the research progress on the function of O islands, especially focusing on virulence-related O islands.
ISSN:	1949-0976 1949-0984
DOI:	10.1080/19490976.2021.1992237