The effect of early probiotic exposure on the preterm infant gut microbiome development

Premature birth, especially if born before week 32 of gestation, is associated with increased risk of neonatal morbidity and mortality. Prophylactic use of probiotics has been suggested to protect preterm infants via supporting a healthy gut microbiota (GM) development, but the suggested strains and...

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Veröffentlicht in:	Gut microbes 2021-01, Vol.13 (1), p.1951113-1951113
Hauptverfasser:	Hui, Yan, Smith, Birgitte, Mortensen, Martin Steen, Krych, Lukasz, Sørensen, Søren J., Greisen, Gorm, Krogfelt, Karen Angeliki, Nielsen, Dennis Sandris
Format:	Artikel
Sprache:	eng
Schlagworte:	amplicon sequencing Bifidobacterium animalis - isolation & purification Cohort Studies Denmark Enterocolitis, Necrotizing - drug therapy Enterocolitis, Necrotizing - immunology Feces - microbiology Female Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - immunology gut microbiome Humans Infant, Newborn Infant, Newborn, Diseases - drug therapy Infant, Newborn, Diseases - immunology Infant, Premature - growth & development Infant, Premature - immunology Lactobacillus - isolation & purification Male necrotizing enterocolitis Preterm probiotics Probiotics - pharmacology Probiotics - therapeutic use Research Paper
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Zusammenfassung:	Premature birth, especially if born before week 32 of gestation, is associated with increased risk of neonatal morbidity and mortality. Prophylactic use of probiotics has been suggested to protect preterm infants via supporting a healthy gut microbiota (GM) development, but the suggested strains and doses vary between studies. In this study, we profiled the GM of 5, 10 and 30-day fecal samples from two cohorts of preterm neonates (born
ISSN:	1949-0976 1949-0984
DOI:	10.1080/19490976.2021.1951113