Morning pseudoneutropenia during clozapine treatment
Summary Clozapine, an atypical antipsychotic drug, is associated with a high risk of neutropenia and agranulocytosis, necessitating the immediate discontinuation of the drug. We report the case of a patient who developed clozapine-induced neutropenia. Assessments revealed a pronounced diurnal variat...
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| Veröffentlicht in: | The world journal of biological psychiatry 2003-10, Vol.4 (4), p.192-194 |
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| container_title | The world journal of biological psychiatry |
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| creator | Esposito, David Aouillé, Jérémie Rouillon, Frédéric Limosin, Frédéric |
| description | Summary
Clozapine, an atypical antipsychotic drug, is associated with a high risk of neutropenia and agranulocytosis, necessitating the immediate discontinuation of the drug. We report the case of a patient who developed clozapine-induced neutropenia. Assessments revealed a pronounced diurnal variation in the number of circulating neutrophils (1200-1900 mm3 in the morning and 2200- 2700 mm3 in the afternoon). Due to these circadian changes, we decided to continue clozapine treatment. |
| doi_str_mv | 10.1080/15622970310029918 |
| format | Article |
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Clozapine, an atypical antipsychotic drug, is associated with a high risk of neutropenia and agranulocytosis, necessitating the immediate discontinuation of the drug. We report the case of a patient who developed clozapine-induced neutropenia. Assessments revealed a pronounced diurnal variation in the number of circulating neutrophils (1200-1900 mm3 in the morning and 2200- 2700 mm3 in the afternoon). Due to these circadian changes, we decided to continue clozapine treatment.</description><identifier>ISSN: 1562-2975</identifier><identifier>EISSN: 1814-1412</identifier><identifier>DOI: 10.1080/15622970310029918</identifier><identifier>PMID: 14608591</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adult ; Antipsychotic Agents - adverse effects ; Antipsychotic Agents - therapeutic use ; Circadian Rhythm ; Clozapine - adverse effects ; Clozapine - therapeutic use ; Humans ; Male ; Neutropenia - chemically induced ; Neutropenia - diagnosis ; Schizophrenia, Paranoid - blood ; Schizophrenia, Paranoid - drug therapy</subject><ispartof>The world journal of biological psychiatry, 2003-10, Vol.4 (4), p.192-194</ispartof><rights>2003 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-845e0a7432249745256bdd6ea2b3d9e0a43e55e587e5898cd21bb76eb48cc7233</citedby><cites>FETCH-LOGICAL-c351t-845e0a7432249745256bdd6ea2b3d9e0a43e55e587e5898cd21bb76eb48cc7233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/15622970310029918$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/15622970310029918$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,61197,61232,61378,61413</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14608591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Esposito, David</creatorcontrib><creatorcontrib>Aouillé, Jérémie</creatorcontrib><creatorcontrib>Rouillon, Frédéric</creatorcontrib><creatorcontrib>Limosin, Frédéric</creatorcontrib><title>Morning pseudoneutropenia during clozapine treatment</title><title>The world journal of biological psychiatry</title><addtitle>World J Biol Psychiatry</addtitle><description>Summary
Clozapine, an atypical antipsychotic drug, is associated with a high risk of neutropenia and agranulocytosis, necessitating the immediate discontinuation of the drug. We report the case of a patient who developed clozapine-induced neutropenia. Assessments revealed a pronounced diurnal variation in the number of circulating neutrophils (1200-1900 mm3 in the morning and 2200- 2700 mm3 in the afternoon). Due to these circadian changes, we decided to continue clozapine treatment.</description><subject>Adult</subject><subject>Antipsychotic Agents - adverse effects</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Circadian Rhythm</subject><subject>Clozapine - adverse effects</subject><subject>Clozapine - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Neutropenia - chemically induced</subject><subject>Neutropenia - diagnosis</subject><subject>Schizophrenia, Paranoid - blood</subject><subject>Schizophrenia, Paranoid - drug therapy</subject><issn>1562-2975</issn><issn>1814-1412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LAzEQxYMotlY_gBfpF1jN5M8mwZMUq0LFi56XbDK1W7rJkt096Kc3pQUPgodhBt7vDbxHyDXQW6Ca3oEsGTOKcqCUGQP6hExBgyhAADvNd9aLDMgJuej7LaVcZeqcTECUVEsDUyJeYwpN-Jx3PY4-BhyHFDsMjZ37Me0Ft4vftmsCzoeEdmgxDJfkbG13PV4d94x8LB_fF8_F6u3pZfGwKhyXMBRaSKRWCc6YMEpIJsva-xItq7k3WRIcpUSpVR6jnWdQ16rEWmjnFON8RuDw16XY9wnXVZea1qavCmi1b6D600D23Bw83Vi36H8dx8gZuD8ATVjH1NoN2t2wcTZhtY1jCjnQP-9_ADDJaH0</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>Esposito, David</creator><creator>Aouillé, Jérémie</creator><creator>Rouillon, Frédéric</creator><creator>Limosin, Frédéric</creator><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20031001</creationdate><title>Morning pseudoneutropenia during clozapine treatment</title><author>Esposito, David ; Aouillé, Jérémie ; Rouillon, Frédéric ; Limosin, Frédéric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-845e0a7432249745256bdd6ea2b3d9e0a43e55e587e5898cd21bb76eb48cc7233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Antipsychotic Agents - adverse effects</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Circadian Rhythm</topic><topic>Clozapine - adverse effects</topic><topic>Clozapine - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Neutropenia - chemically induced</topic><topic>Neutropenia - diagnosis</topic><topic>Schizophrenia, Paranoid - blood</topic><topic>Schizophrenia, Paranoid - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Esposito, David</creatorcontrib><creatorcontrib>Aouillé, Jérémie</creatorcontrib><creatorcontrib>Rouillon, Frédéric</creatorcontrib><creatorcontrib>Limosin, Frédéric</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The world journal of biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Esposito, David</au><au>Aouillé, Jérémie</au><au>Rouillon, Frédéric</au><au>Limosin, Frédéric</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morning pseudoneutropenia during clozapine treatment</atitle><jtitle>The world journal of biological psychiatry</jtitle><addtitle>World J Biol Psychiatry</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>4</volume><issue>4</issue><spage>192</spage><epage>194</epage><pages>192-194</pages><issn>1562-2975</issn><eissn>1814-1412</eissn><abstract>Summary
Clozapine, an atypical antipsychotic drug, is associated with a high risk of neutropenia and agranulocytosis, necessitating the immediate discontinuation of the drug. We report the case of a patient who developed clozapine-induced neutropenia. Assessments revealed a pronounced diurnal variation in the number of circulating neutrophils (1200-1900 mm3 in the morning and 2200- 2700 mm3 in the afternoon). Due to these circadian changes, we decided to continue clozapine treatment.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>14608591</pmid><doi>10.1080/15622970310029918</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adult Antipsychotic Agents - adverse effects Antipsychotic Agents - therapeutic use Circadian Rhythm Clozapine - adverse effects Clozapine - therapeutic use Humans Male Neutropenia - chemically induced Neutropenia - diagnosis Schizophrenia, Paranoid - blood Schizophrenia, Paranoid - drug therapy |
| title | Morning pseudoneutropenia during clozapine treatment |
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