Morning pseudoneutropenia during clozapine treatment

Summary Clozapine, an atypical antipsychotic drug, is associated with a high risk of neutropenia and agranulocytosis, necessitating the immediate discontinuation of the drug. We report the case of a patient who developed clozapine-induced neutropenia. Assessments revealed a pronounced diurnal variat...

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Veröffentlicht in:	The world journal of biological psychiatry 2003-10, Vol.4 (4), p.192-194
Hauptverfasser:	Esposito, David, Aouillé, Jérémie, Rouillon, Frédéric, Limosin, Frédéric
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antipsychotic Agents - adverse effects Antipsychotic Agents - therapeutic use Circadian Rhythm Clozapine - adverse effects Clozapine - therapeutic use Humans Male Neutropenia - chemically induced Neutropenia - diagnosis Schizophrenia, Paranoid - blood Schizophrenia, Paranoid - drug therapy
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Beschreibung
Zusammenfassung:	Summary Clozapine, an atypical antipsychotic drug, is associated with a high risk of neutropenia and agranulocytosis, necessitating the immediate discontinuation of the drug. We report the case of a patient who developed clozapine-induced neutropenia. Assessments revealed a pronounced diurnal variation in the number of circulating neutrophils (1200-1900 mm3 in the morning and 2200- 2700 mm3 in the afternoon). Due to these circadian changes, we decided to continue clozapine treatment.
ISSN:	1562-2975 1814-1412
DOI:	10.1080/15622970310029918