Adiposity associated DNA methylation signatures in adolescents are related to leptin and perinatal factors

Epigenetics links perinatal influences with later obesity. We identifed differentially methylated CpG (dmCpG) loci measured at 17 years associated with concurrent adiposity measures and examined whether these were associated with hsCRP, adipokines, and early life environmental factors. Genome-wide D...

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Veröffentlicht in:	Epigenetics 2022-08, Vol.17 (8), p.819-836
Hauptverfasser:	Huang, R.C., Melton, P.E., Burton, M.A., Beilin, L.J., Clarke-Harris, R, Cook, E, Godfrey, K.M., Burdge, G.C., Mori, T.A., Anderson, D, Rauschert, S., Craig, J. M., Kobor, M.S., MacIsaac, J.L., Morin, A.M., Oddy, W.H., Pennell, C.E., Holbrook, J.D., Lillycrop, K.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	adiposity Adiposity - genetics adolescence Adolescent body Composition Body Mass Index Dicarboxylic Acid Transporters - genetics Dicarboxylic Acid Transporters - metabolism DNA - metabolism DNA Methylation epigenetic Variation Female high-sensitivity C-reactive Protein Humans inflammation leptin Leptin - genetics Leptin - metabolism maternal Obesity - genetics Obesity - metabolism Pregnancy Research Paper RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism the Raine Study Young Adult youth
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Zusammenfassung:	Epigenetics links perinatal influences with later obesity. We identifed differentially methylated CpG (dmCpG) loci measured at 17 years associated with concurrent adiposity measures and examined whether these were associated with hsCRP, adipokines, and early life environmental factors. Genome-wide DNA methylation from 1192 Raine Study participants at 17 years, identified 29 dmCpGs (Bonferroni corrected p
ISSN:	1559-2294 1559-2308
DOI:	10.1080/15592294.2021.1876297