Computer Aided Design of Triplet Forming Artificial Nucleobases

Computer Aided Design of Triplet Forming Artificial Nucleobases

Triplex forming oligonucleotides could prevent genetic transcription at the level of genes. Nucleotide bases with the capability of specific H-bonding interactions with base pairs in the major groove of DNA have been designed. Calculations by semiempirical methods lead to four compounds as possible...

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Veröffentlicht in:Nucleosides & nucleotides 1999-04, Vol.18 (4-5), p.1127-1129
Hauptverfasser: Fenyõ, R., Timár, Z., Pálinkó, I., Penke, B.
Format: Artikel
Sprache:eng
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Zusammenfassung:Triplex forming oligonucleotides could prevent genetic transcription at the level of genes. Nucleotide bases with the capability of specific H-bonding interactions with base pairs in the major groove of DNA have been designed. Calculations by semiempirical methods lead to four compounds as possible triplet forming nucleobases.
ISSN:0732-8311
2332-3892
DOI:10.1080/15257779908041667