Postsynthetic Transformations of Oligodeoxynucleotides Originated at 6-Methylthio-purine Site

Postsynthetic Transformations of Oligodeoxynucleotides Originated at 6-Methylthio-purine Site

New route to oligodeoxynucleotides labeled with fluorescent luminarine was explored. Regioselective oxidation of 6-methylthio-purines to 6-methylsulphoxides reactive toward pyridine was achieved. Upon UV irradiation of 6-pyridinium-purines oligonucleotide cleavage instead of phototransformation to l...

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Veröffentlicht in:Nucleosides & nucleotides 1995-05, Vol.14 (3-5), p.979-982
Hauptverfasser: Burdzy, Artur, Skalski, Bohdan, Biał, Ewa, Kowalewski, Andrzej, Paszyc, Stefan, Adamiak, Rys2ard W.
Format: Artikel
Sprache:eng
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Zusammenfassung:New route to oligodeoxynucleotides labeled with fluorescent luminarine was explored. Regioselective oxidation of 6-methylthio-purines to 6-methylsulphoxides reactive toward pyridine was achieved. Upon UV irradiation of 6-pyridinium-purines oligonucleotide cleavage instead of phototransformation to luminarine was observed.
ISSN:0732-8311
1525-7770
DOI:10.1080/15257779508012515