Synthesis of Circular Oligodeoxynucleotide Conjugates VIA Transient Abasic Sites

Synthesis of Circular Oligodeoxynucleotide Conjugates VIA Transient Abasic Sites

New chemical ligation or cyclisation reactions, using high reactivity of abasic sites with amines, are reported for the synthesis of oligonucleotide clamps and singlestranded circular oligonucleotides. Thermal denaturation experiments show that these molecules display very high binding affinities fo...

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Veröffentlicht in:Nucleosides & nucleotides 1995-05, Vol.14 (3-5), p.847-850
Hauptverfasser: Péoc'h, D., Imbach, J.-L., Rayner, B.
Format: Artikel
Sprache:eng
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Zusammenfassung:New chemical ligation or cyclisation reactions, using high reactivity of abasic sites with amines, are reported for the synthesis of oligonucleotide clamps and singlestranded circular oligonucleotides. Thermal denaturation experiments show that these molecules display very high binding affinities for complementary DNA oligomer by forming triple-helical complexes.
ISSN:0732-8311
1525-7770
DOI:10.1080/15257779508012486