Substrate Specificities of Mitochondrial Thymidine Kinase and Cytosolic Deoxycytidine Kinase Against 5-Aryl Substituted Pyrimidine-2′-deoxyribose Analogues

Some 5-aryl-2′-deoxyuridine and -deoxycytidine analogues, many with known antiviral activity, were evaluated as substrates for pure deoxycytidine kinase (dCK) and pure mitochondrial thymidine kinase (TK2). Some of the deoxyuridine compounds were also tested with pure cytosolic thymidine kinase (TK1)...

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Veröffentlicht in:Nucleosides & nucleotides 1995-05, Vol.14 (3-5), p.507-510
Hauptverfasser: Eriksson, Staffan, Wang, Jianghai, Gronowitz, Salo, Johansson, Nils Gunnar
Format: Artikel
Sprache:eng
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Zusammenfassung:Some 5-aryl-2′-deoxyuridine and -deoxycytidine analogues, many with known antiviral activity, were evaluated as substrates for pure deoxycytidine kinase (dCK) and pure mitochondrial thymidine kinase (TK2). Some of the deoxyuridine compounds were also tested with pure cytosolic thymidine kinase (TK1). TK2 showed the highest activity with this type of analogues.
ISSN:0732-8311
1525-7770
2332-3892
DOI:10.1080/15257779508012414