Synthesis of 3′-4′-α-Propylene-2′-3′-dideoxynucleosides

In order to obtain a high degree of rigidity within the sugar moiety of nucleosides, some bicyclic pyrimidine nucleoside analogues where synthesized starting from cyclopentanone. The C-4′-substituent is fused to the C-3′-position via a propylene to give a [3.3.0]-bicyclic ring system.

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Veröffentlicht in:Nucleosides & nucleotides 1995-05, Vol.14 (3-5), p.279-282
Hauptverfasser: Björsne, Magnus, Szabó, Tomas, Samuelsson, Bertil, Classon, Björn
Format: Artikel
Sprache:eng
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Zusammenfassung:In order to obtain a high degree of rigidity within the sugar moiety of nucleosides, some bicyclic pyrimidine nucleoside analogues where synthesized starting from cyclopentanone. The C-4′-substituent is fused to the C-3′-position via a propylene to give a [3.3.0]-bicyclic ring system.
ISSN:0732-8311
1525-7770
DOI:10.1080/15257779508012361