Palladium Catalysis in the Synthesis of 8-Position modified Adenosine, 2′-Deoxyadenosine and Guanosine

Palladium Catalysis in the Synthesis of 8-Position modified Adenosine, 2′-Deoxyadenosine and Guanosine

Adenosine and guanosine analogs with 8-position vinyl and aryl groups were prepared by palladium catalyzed cross-coupling of organostannanes with 8-bromopurine nucleosides. The reaction conditions and catalyst composition were improved so that both vinyl and aryl modifications could be made by a gen...

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Veröffentlicht in:Nucleosides & nucleotides 1995-10, Vol.14 (8), p.1631-1638
Hauptverfasser: Tu, Chi, Keane, Charlene, Eaton, Bruce E.
Format: Artikel
Sprache:eng
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Zusammenfassung:Adenosine and guanosine analogs with 8-position vinyl and aryl groups were prepared by palladium catalyzed cross-coupling of organostannanes with 8-bromopurine nucleosides. The reaction conditions and catalyst composition were improved so that both vinyl and aryl modifications could be made by a general procedure.
ISSN:0732-8311
DOI:10.1080/15257779508009745