Thiol‐Oxidizing Agent Diamide and Acidic pH Enhance Lipid Peroxidation of Rat Heart Mitochondria and Cardiolipin? Cytochrome c Complex

Thiol‐Oxidizing Agent Diamide and Acidic pH Enhance Lipid Peroxidation of Rat Heart Mitochondria and Cardiolipin? Cytochrome c Complex

In this study, we investigated lipid peroxidation in rat heart mitochondria hydrolyzed by phospholipase A2 (PLA2) and lipid peroxidation in a mitochondrial‐mimetic lipid peroxidation system, where phospholipids such as cardiolipin (CL) and cytochrome c (Cyt c) were first mixed together and then PLA2...

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Veröffentlicht in:IUBMB life 2001-01, Vol.51 (1), p.39-43
Hauptverfasser: Iwase, Hirotaro, Sakurada, Koichi, Ikegaya, Hiroshi, Hatanaka, Kazuhito, Takeichi, Hisako, Kobayashi, Masahiko, Yoshida, Kenichi
Format: Artikel
Sprache:eng
Schlagworte:
Acid
Cardiolipin
Cytochrome
Free
Linoleic
Lipid
Mitochondria
Peroxidation
Radical
Thiol
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Beschreibung
Zusammenfassung:In this study, we investigated lipid peroxidation in rat heart mitochondria hydrolyzed by phospholipase A2 (PLA2) and lipid peroxidation in a mitochondrial‐mimetic lipid peroxidation system, where phospholipids such as cardiolipin (CL) and cytochrome c (Cyt c) were first mixed together and then PLA2 and calcium chloride were added to the mixture (CL‐Cyt c‐PLA2 system). Production of hydroperoxy and hydroxy compounds of linoleic acid (LA)1
ISSN:1521-6543
1521-6551
DOI:10.1080/15216540117251