Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin - piperine nutraceutical system with improved enzyme inhibition properties
The nutraceutical system of curcumin-piperine in 2-hydroxypropyl-β-cyclodextrin was prepared by using the kneading technique. Interactions between the components of the system were defined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), nuc...
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| Veröffentlicht in: | Journal of enzyme inhibition and medicinal chemistry 2020-01, Vol.35 (1), p.1811-1821 |
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| container_title | Journal of enzyme inhibition and medicinal chemistry |
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| creator | Stasiłowicz, Anna Tykarska, Ewa Lewandowska, Kornelia Kozak, Maciej Miklaszewski, Andrzej Kobus-Cisowska, Joanna Szymanowska, Daria Plech, Tomasz Jenczyk, Jacek Cielecka-Piontek, Judyta |
| description | The nutraceutical system of curcumin-piperine in 2-hydroxypropyl-β-cyclodextrin was prepared by using the kneading technique. Interactions between the components of the system were defined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR). Application of hydroxypropyl-β-cyclodextrin as a carrier-solubiliser improved solubility of the curcumin-piperine system, its permeability through biological membranes (gastrointestinal tract, blood-brain barrier) as well as the antioxidant, antimicrobial and enzyme inhibitory activities against acetylcholinesterase and butyrylcholinesterase. |
| doi_str_mv | 10.1080/14756366.2020.1801670 |
| format | Article |
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Interactions between the components of the system were defined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR). Application of hydroxypropyl-β-cyclodextrin as a carrier-solubiliser improved solubility of the curcumin-piperine system, its permeability through biological membranes (gastrointestinal tract, blood-brain barrier) as well as the antioxidant, antimicrobial and enzyme inhibitory activities against acetylcholinesterase and butyrylcholinesterase.</description><identifier>ISSN: 1475-6366</identifier><identifier>EISSN: 1475-6374</identifier><identifier>DOI: 10.1080/14756366.2020.1801670</identifier><identifier>PMID: 32967477</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>2-Hydroxypropyl-beta-cyclodextrin - chemistry ; Acetylcholinesterase ; Acetylcholinesterase - metabolism ; Alkaloids - chemistry ; Alkaloids - pharmacology ; Anti-Infective Agents - chemistry ; Anti-Infective Agents - pharmacology ; Antioxidants ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Benzodioxoles - chemistry ; Benzodioxoles - pharmacology ; Biological Transport ; Blood-brain barrier ; Blood-Brain Barrier - metabolism ; Butyrylcholinesterase - metabolism ; Cholinesterase Inhibitors - chemistry ; Cholinesterase Inhibitors - pharmacology ; Curcumin ; Curcumin - chemistry ; Curcumin - pharmacology ; cyclodextrin ; Dietary Supplements ; Differential scanning calorimetry ; Drug Carriers - chemistry ; Drug Compounding ; Enzymes ; Functional foods & nutraceuticals ; Gastrointestinal tract ; Gastrointestinal Tract - metabolism ; Humans ; hyaluronidase ; Infrared spectroscopy ; Membrane permeability ; NMR ; Nuclear magnetic resonance ; Piperidines - chemistry ; Piperidines - pharmacology ; Piperine ; Polyunsaturated Alkamides - chemistry ; Polyunsaturated Alkamides - pharmacology ; Research Paper ; Solubility ; β-Cyclodextrin</subject><ispartof>Journal of enzyme inhibition and medicinal chemistry, 2020-01, Vol.35 (1), p.1811-1821</ispartof><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2020</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2020 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-e56a36e8152829a11f44bee83f92a35f38b04f0e48b9ef3fa2e98dcc81493c213</citedby><cites>FETCH-LOGICAL-c562t-e56a36e8152829a11f44bee83f92a35f38b04f0e48b9ef3fa2e98dcc81493c213</cites><orcidid>0000-0001-5211-661X ; 0000-0001-9393-3536 ; 0000-0001-6792-4281 ; 0000-0003-2834-0405 ; 0000-0003-1700-6719 ; 0000-0002-4665-1576 ; 0000-0003-0891-5419 ; 0000-0003-3312-6518 ; 0000-0002-2063-7805 ; 0000-0002-8162-8435</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534320/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534320/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,27502,27924,27925,53791,53793,59143,59144</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32967477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stasiłowicz, Anna</creatorcontrib><creatorcontrib>Tykarska, Ewa</creatorcontrib><creatorcontrib>Lewandowska, Kornelia</creatorcontrib><creatorcontrib>Kozak, Maciej</creatorcontrib><creatorcontrib>Miklaszewski, Andrzej</creatorcontrib><creatorcontrib>Kobus-Cisowska, Joanna</creatorcontrib><creatorcontrib>Szymanowska, Daria</creatorcontrib><creatorcontrib>Plech, Tomasz</creatorcontrib><creatorcontrib>Jenczyk, Jacek</creatorcontrib><creatorcontrib>Cielecka-Piontek, Judyta</creatorcontrib><title>Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin - piperine nutraceutical system with improved enzyme inhibition properties</title><title>Journal of enzyme inhibition and medicinal chemistry</title><addtitle>J Enzyme Inhib Med Chem</addtitle><description>The nutraceutical system of curcumin-piperine in 2-hydroxypropyl-β-cyclodextrin was prepared by using the kneading technique. Interactions between the components of the system were defined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR). Application of hydroxypropyl-β-cyclodextrin as a carrier-solubiliser improved solubility of the curcumin-piperine system, its permeability through biological membranes (gastrointestinal tract, blood-brain barrier) as well as the antioxidant, antimicrobial and enzyme inhibitory activities against acetylcholinesterase and butyrylcholinesterase.</description><subject>2-Hydroxypropyl-beta-cyclodextrin - chemistry</subject><subject>Acetylcholinesterase</subject><subject>Acetylcholinesterase - metabolism</subject><subject>Alkaloids - chemistry</subject><subject>Alkaloids - pharmacology</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antioxidants</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>Benzodioxoles - chemistry</subject><subject>Benzodioxoles - pharmacology</subject><subject>Biological Transport</subject><subject>Blood-brain barrier</subject><subject>Blood-Brain Barrier - metabolism</subject><subject>Butyrylcholinesterase - metabolism</subject><subject>Cholinesterase Inhibitors - chemistry</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>Curcumin</subject><subject>Curcumin - chemistry</subject><subject>Curcumin - pharmacology</subject><subject>cyclodextrin</subject><subject>Dietary Supplements</subject><subject>Differential scanning calorimetry</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Compounding</subject><subject>Enzymes</subject><subject>Functional foods & nutraceuticals</subject><subject>Gastrointestinal tract</subject><subject>Gastrointestinal Tract - metabolism</subject><subject>Humans</subject><subject>hyaluronidase</subject><subject>Infrared spectroscopy</subject><subject>Membrane permeability</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Piperidines - chemistry</subject><subject>Piperidines - pharmacology</subject><subject>Piperine</subject><subject>Polyunsaturated Alkamides - 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piperine nutraceutical system with improved enzyme inhibition properties</title><author>Stasiłowicz, Anna ; Tykarska, Ewa ; Lewandowska, Kornelia ; Kozak, Maciej ; Miklaszewski, Andrzej ; Kobus-Cisowska, Joanna ; Szymanowska, Daria ; Plech, Tomasz ; Jenczyk, Jacek ; Cielecka-Piontek, Judyta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-e56a36e8152829a11f44bee83f92a35f38b04f0e48b9ef3fa2e98dcc81493c213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>2-Hydroxypropyl-beta-cyclodextrin - chemistry</topic><topic>Acetylcholinesterase</topic><topic>Acetylcholinesterase - metabolism</topic><topic>Alkaloids - chemistry</topic><topic>Alkaloids - pharmacology</topic><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antioxidants</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - pharmacology</topic><topic>Benzodioxoles - chemistry</topic><topic>Benzodioxoles - pharmacology</topic><topic>Biological Transport</topic><topic>Blood-brain barrier</topic><topic>Blood-Brain Barrier - metabolism</topic><topic>Butyrylcholinesterase - metabolism</topic><topic>Cholinesterase Inhibitors - chemistry</topic><topic>Cholinesterase Inhibitors - pharmacology</topic><topic>Curcumin</topic><topic>Curcumin - chemistry</topic><topic>Curcumin - pharmacology</topic><topic>cyclodextrin</topic><topic>Dietary Supplements</topic><topic>Differential scanning calorimetry</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Compounding</topic><topic>Enzymes</topic><topic>Functional foods & nutraceuticals</topic><topic>Gastrointestinal tract</topic><topic>Gastrointestinal Tract - metabolism</topic><topic>Humans</topic><topic>hyaluronidase</topic><topic>Infrared spectroscopy</topic><topic>Membrane permeability</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Piperidines - chemistry</topic><topic>Piperidines - pharmacology</topic><topic>Piperine</topic><topic>Polyunsaturated Alkamides - chemistry</topic><topic>Polyunsaturated Alkamides - pharmacology</topic><topic>Research Paper</topic><topic>Solubility</topic><topic>β-Cyclodextrin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stasiłowicz, Anna</creatorcontrib><creatorcontrib>Tykarska, Ewa</creatorcontrib><creatorcontrib>Lewandowska, Kornelia</creatorcontrib><creatorcontrib>Kozak, Maciej</creatorcontrib><creatorcontrib>Miklaszewski, Andrzej</creatorcontrib><creatorcontrib>Kobus-Cisowska, Joanna</creatorcontrib><creatorcontrib>Szymanowska, Daria</creatorcontrib><creatorcontrib>Plech, Tomasz</creatorcontrib><creatorcontrib>Jenczyk, Jacek</creatorcontrib><creatorcontrib>Cielecka-Piontek, Judyta</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of enzyme inhibition and medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stasiłowicz, Anna</au><au>Tykarska, Ewa</au><au>Lewandowska, Kornelia</au><au>Kozak, Maciej</au><au>Miklaszewski, Andrzej</au><au>Kobus-Cisowska, Joanna</au><au>Szymanowska, Daria</au><au>Plech, Tomasz</au><au>Jenczyk, Jacek</au><au>Cielecka-Piontek, Judyta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin - 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Interactions between the components of the system were defined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR). Application of hydroxypropyl-β-cyclodextrin as a carrier-solubiliser improved solubility of the curcumin-piperine system, its permeability through biological membranes (gastrointestinal tract, blood-brain barrier) as well as the antioxidant, antimicrobial and enzyme inhibitory activities against acetylcholinesterase and butyrylcholinesterase.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>32967477</pmid><doi>10.1080/14756366.2020.1801670</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-5211-661X</orcidid><orcidid>https://orcid.org/0000-0001-9393-3536</orcidid><orcidid>https://orcid.org/0000-0001-6792-4281</orcidid><orcidid>https://orcid.org/0000-0003-2834-0405</orcidid><orcidid>https://orcid.org/0000-0003-1700-6719</orcidid><orcidid>https://orcid.org/0000-0002-4665-1576</orcidid><orcidid>https://orcid.org/0000-0003-0891-5419</orcidid><orcidid>https://orcid.org/0000-0003-3312-6518</orcidid><orcidid>https://orcid.org/0000-0002-2063-7805</orcidid><orcidid>https://orcid.org/0000-0002-8162-8435</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 2-Hydroxypropyl-beta-cyclodextrin - chemistry Acetylcholinesterase Acetylcholinesterase - metabolism Alkaloids - chemistry Alkaloids - pharmacology Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antioxidants Antioxidants - chemistry Antioxidants - pharmacology Benzodioxoles - chemistry Benzodioxoles - pharmacology Biological Transport Blood-brain barrier Blood-Brain Barrier - metabolism Butyrylcholinesterase - metabolism Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Curcumin Curcumin - chemistry Curcumin - pharmacology cyclodextrin Dietary Supplements Differential scanning calorimetry Drug Carriers - chemistry Drug Compounding Enzymes Functional foods & nutraceuticals Gastrointestinal tract Gastrointestinal Tract - metabolism Humans hyaluronidase Infrared spectroscopy Membrane permeability NMR Nuclear magnetic resonance Piperidines - chemistry Piperidines - pharmacology Piperine Polyunsaturated Alkamides - chemistry Polyunsaturated Alkamides - pharmacology Research Paper Solubility β-Cyclodextrin |
| title | Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin - piperine nutraceutical system with improved enzyme inhibition properties |
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