Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin - piperine nutraceutical system with improved enzyme inhibition properties

The nutraceutical system of curcumin-piperine in 2-hydroxypropyl-β-cyclodextrin was prepared by using the kneading technique. Interactions between the components of the system were defined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), nuc...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2020-01, Vol.35 (1), p.1811-1821
Hauptverfasser:	Stasiłowicz, Anna, Tykarska, Ewa, Lewandowska, Kornelia, Kozak, Maciej, Miklaszewski, Andrzej, Kobus-Cisowska, Joanna, Szymanowska, Daria, Plech, Tomasz, Jenczyk, Jacek, Cielecka-Piontek, Judyta
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Hydroxypropyl-beta-cyclodextrin - chemistry Acetylcholinesterase Acetylcholinesterase - metabolism Alkaloids - chemistry Alkaloids - pharmacology Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antioxidants Antioxidants - chemistry Antioxidants - pharmacology Benzodioxoles - chemistry Benzodioxoles - pharmacology Biological Transport Blood-brain barrier Blood-Brain Barrier - metabolism Butyrylcholinesterase - metabolism Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Curcumin Curcumin - chemistry Curcumin - pharmacology cyclodextrin Dietary Supplements Differential scanning calorimetry Drug Carriers - chemistry Drug Compounding Enzymes Functional foods & nutraceuticals Gastrointestinal tract Gastrointestinal Tract - metabolism Humans hyaluronidase Infrared spectroscopy Membrane permeability NMR Nuclear magnetic resonance Piperidines - chemistry Piperidines - pharmacology Piperine Polyunsaturated Alkamides - chemistry Polyunsaturated Alkamides - pharmacology Research Paper Solubility β-Cyclodextrin
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Zusammenfassung:	The nutraceutical system of curcumin-piperine in 2-hydroxypropyl-β-cyclodextrin was prepared by using the kneading technique. Interactions between the components of the system were defined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR). Application of hydroxypropyl-β-cyclodextrin as a carrier-solubiliser improved solubility of the curcumin-piperine system, its permeability through biological membranes (gastrointestinal tract, blood-brain barrier) as well as the antioxidant, antimicrobial and enzyme inhibitory activities against acetylcholinesterase and butyrylcholinesterase.
ISSN:	1475-6366 1475-6374
DOI:	10.1080/14756366.2020.1801670