Development of a hybrid liver-support device

The development of an extracorporeal hybrid liver-support system using hepatocytes and an artificial device has been long awaited for the treatment of patients with hepatic failure. During the past decade important progress has been made in biotechnology and bioengineering, and a hybrid liver-suppor...

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Veröffentlicht in:Minimally invasive therapy and allied technologies 2002, Vol.11 (3), p.123-134
Hauptverfasser: Bartolo, L. De, Bader, A.
Format: Artikel
Sprache:eng
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Zusammenfassung:The development of an extracorporeal hybrid liver-support system using hepatocytes and an artificial device has been long awaited for the treatment of patients with hepatic failure. During the past decade important progress has been made in biotechnology and bioengineering, and a hybrid liver-support device using metabolically active hepatocytes may well become a reality in the near future. This paper outlines recent developments in bioreactor systems used as bioartificial liver-support devices, and focuses on critical issues for bioreactor design, main transport features and culture techniques for hepatocytes. We describe our bioreactor, which uses porcine hepatocytes, and the scaling-up of the device. The biochemical performance of such a device is comparable to that of those developed by other researchers, and we feel encouraged to perform in vivo experiments on animal models in order to evaluate the potential of the device as a bioartificial liver.
ISSN:1364-5706
1365-2931
DOI:10.1080/136457002320174195