NO Synthesis in Human Saliva

Human saliva contains nitrate that is converted into nitrite by the activity of facultative, anaerobic bacteria of the oral cavity. Nitrite can be reduced to NO in the acidic gastric milieu; some NO may also form in the mouth at acidic pH values. In this paper, we show that bacteria ( S. salivarius,...

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Veröffentlicht in:	Free radical research 2003, Vol.37 (1), p.29-31
Hauptverfasser:	Palmerini, C.A., Palombari, R., Perito, S., Arienti, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amperometric Sensor Anti-Bacterial Agents - metabolism Bacteria Female Humans Hydrogen-Ion Concentration In Vitro Techniques Nitric Oxide - biosynthesis Nitrite Nitrites - metabolism Saliva Saliva - metabolism Saliva - microbiology Streptococcus - isolation & purification Streptococcus - metabolism Streptococcus bovis - isolation & purification Streptococcus bovis - metabolism Streptococcus mitis - isolation & purification Streptococcus mitis - metabolism Streptococcus Salivarius
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Beschreibung
Zusammenfassung:	Human saliva contains nitrate that is converted into nitrite by the activity of facultative, anaerobic bacteria of the oral cavity. Nitrite can be reduced to NO in the acidic gastric milieu; some NO may also form in the mouth at acidic pH values. In this paper, we show that bacteria ( S. salivarius, S. mitis and S. bovis ) isolated from saliva, may contribute to NO production in human saliva. NO formation by bacteria occurs at neutral pH values and may contribute to the antibacterial activity of saliva.
ISSN:	1071-5762 1029-2470
DOI:	10.1080/1071576021000028398