Expression of NEDD4L and ENaC in Urinary Extracellular Vesicles in Pre-eclampsia

Expression of NEDD4L and ENaC in Urinary Extracellular Vesicles in Pre-eclampsia

To assess changes in expression of renal epithelial sodium channel (ENaC) and NEDD4L, a ubiquitin ligase, in urinary extracellular vesicles (UEV) of pre-eclamptic women compared to normal pregnant controls. Urine was collected from pre-eclamptic women (PE, n = 20) or during normal pregnancy (NP, n =...

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Veröffentlicht in:Hypertension in pregnancy 2023-12, Vol.42 (1), p.2232029-2232029
Hauptverfasser: Leung, P.Y.M., Katerelos, M, Choy, S., Cook, N, Lee, M, Paizis, K, Abboud, A, Manning, J. A., Mount, P.F, Power, D.A
Format: Artikel
Sprache:eng
Schlagworte:
epithelial sodium channel
NEDD4L
Pre-eclampsia
ubiquitin ligase
urinary extracellular vesicles
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Zusammenfassung:To assess changes in expression of renal epithelial sodium channel (ENaC) and NEDD4L, a ubiquitin ligase, in urinary extracellular vesicles (UEV) of pre-eclamptic women compared to normal pregnant controls. Urine was collected from pre-eclamptic women (PE, n = 20) or during normal pregnancy (NP, n = 20). UEV were separated by differential ultracentrifugation. NEDD4L, α-ENaC and γ-ENaC were identified by immunoblotting. There was no difference in the expression of NEDD4L (p = 0.17) and α-ENaC (p = 0.10). PE subjects showed increased expression of γ-ENaC by 6.9-fold compared to NP (p 
ISSN:1064-1955
1525-6065
DOI:10.1080/10641955.2023.2232029