Current Progress on Statistical Methods for Mapping Quantitative Trait Loci from Inbred Line Crosses

Current Progress on Statistical Methods for Mapping Quantitative Trait Loci from Inbred Line Crosses

Tremendous progress has been made in recent years on developing statistical methods for mapping quantitative trait loci (QTL) from crosses of inbred lines. Most of the recent research is focused on strategies for mapping multiple-QTL and associated model selection procedures and criterion. We review...

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Veröffentlicht in:Journal of biopharmaceutical statistics 2010-03, Vol.20 (2), p.454-481
Hauptverfasser: E Silva, Luciano Da Costa, Zeng, Zhao-Bang
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
Animals
Animals, Inbred Strains
Bayes Theorem
Bayesian analysis
Biostatistics
Crosses, Genetic
Data Interpretation, Statistical
Gene loci
Genome-Wide Association Study - statistics & numerical data
Genomics
Genotype
Inbred lines
Likelihood Functions
Maximum likelihood method
Models, Statistical
Phenotype
Quantitative Trait Loci
Reproducibility of Results
Statistical methods
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Beschreibung
Zusammenfassung:Tremendous progress has been made in recent years on developing statistical methods for mapping quantitative trait loci (QTL) from crosses of inbred lines. Most of the recent research is focused on strategies for mapping multiple-QTL and associated model selection procedures and criterion. We review the progress of research in this area on one trait and multiple traits by maximum likelihood and Bayesian methods.
ISSN:1054-3406
1520-5711
DOI:10.1080/10543400903572845