SYNTHESIS OF NOVEL C-ORGANOSILICON DERIVATIVES, POTENTIAL INHIBITORS OF HIV REVERSE TRANSCRIPTION

SYNTHESIS OF NOVEL C-ORGANOSILICON DERIVATIVES, POTENTIAL INHIBITORS OF HIV REVERSE TRANSCRIPTION

A series of silylated nucleobases was synthesized as potential therapeutic agents against HIV. These compounds were designed to interact with the active site of HIV Reverse Transcriptase (RT). Such molecules might therefore inhibit the reverse transcription process of the virus.

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Bibliographische Detailangaben
Veröffentlicht in:Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 1995-05, Vol.102 (1-4), p.155-168
Hauptverfasser: Lafay, Jean, Latxague, Laurent, Lacroix, Christine, Déléris, Gérard
Format: Artikel
Sprache:eng
Schlagworte:
HIV
Nucleobases
reverse transcriptase
silanols
siloxane 2D-NMR
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Beschreibung
Zusammenfassung:A series of silylated nucleobases was synthesized as potential therapeutic agents against HIV. These compounds were designed to interact with the active site of HIV Reverse Transcriptase (RT). Such molecules might therefore inhibit the reverse transcription process of the virus.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426509508042553