Elucidation of colon-protective efficacy of diosgenin in experimental TNBS-induced colitis: inhibition of NF-κB/IkB-α and Bax/Caspase-1 signaling pathways

The aim of present investigation was to elucidate the unrevealed beneficial role of diosgenin against an experimental model of TNBS (2,4,6-trinitrobenzenesufonic acid)-induced ulcerative colitis (UC). Colitis was induced in Sprague-Dawley rats by intrarectal administration of TNBS (in 50% ethanol)....

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2020-09, Vol.84 (9), p.1903-1912
Hauptverfasser:	Tang, Xiaobo, Huang, Gengzhen, Zhang, Tao, Li, Shiqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bax bcl-2-Associated X Protein - metabolism Biomarkers - metabolism Caspase 1 - metabolism Colitis - chemically induced Colitis - metabolism Colitis - pathology Colon - drug effects Colon - metabolism Colon - pathology Cytoprotection - drug effects diosgenin Diosgenin - pharmacology Disease Models, Animal Male NF-kappa B - metabolism NF-KappaB Inhibitor alpha - metabolism NF-κB Rats Rats, Sprague-Dawley Signal Transduction - drug effects TNBS Trinitrobenzenesulfonic Acid - adverse effects ulcerative colitis
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Zusammenfassung:	The aim of present investigation was to elucidate the unrevealed beneficial role of diosgenin against an experimental model of TNBS (2,4,6-trinitrobenzenesufonic acid)-induced ulcerative colitis (UC). Colitis was induced in Sprague-Dawley rats by intrarectal administration of TNBS (in 50% ethanol). Then animals were treated with diosgenin (50, 100, and 200 mg/kg) for 14 days. Various biochemical, behavioral, molecular, and histological analysis was performed. Diosgenin significantly decreased (p
ISSN:	0916-8451 1347-6947
DOI:	10.1080/09168451.2020.1776590