Identification of Reg3β-producing cells using IL-22-stimulated enteroids

Reg3β, a lectin, displays antibacterial activity. This study investigated Reg3β-expressing cells using IL-22-stimulated enteroids. IL-22 stimulation elevated the mRNA and protein levels of Reg3β. IL-22 also increased the mRNA levels of CD133 (a transit-amplifying cell marker) and lysozyme (a Paneth...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2020-03, Vol.84 (3), p.594-597
Hauptverfasser:	Sato, Mika, Inaba, Akihiko, Iwatsuki, Ken, Saito, Yuki, Tadaishi, Miki, Shimizu, Makoto, Kobayashi-Hattori, Kazuo
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Sprache:	eng
Schlagworte:	Animals Biochemistry & Molecular Biology Biomarkers - metabolism Biotechnology & Applied Microbiology Chemistry Chemistry, Applied Enteroids Food Science & Technology IL-22 Interleukin-22 Interleukins - pharmacology Lectins - biosynthesis Lectins - genetics Lectins - metabolism Life Sciences & Biomedicine Paneth cells Paneth Cells - drug effects Paneth Cells - metabolism Physical Sciences Reg3β Science & Technology
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creator	Sato, Mika Inaba, Akihiko Iwatsuki, Ken Saito, Yuki Tadaishi, Miki Shimizu, Makoto Kobayashi-Hattori, Kazuo
description	Reg3β, a lectin, displays antibacterial activity. This study investigated Reg3β-expressing cells using IL-22-stimulated enteroids. IL-22 stimulation elevated the mRNA and protein levels of Reg3β. IL-22 also increased the mRNA levels of CD133 (a transit-amplifying cell marker) and lysozyme (a Paneth cell marker). Immunohistochemistry showed partial colocalization of Reg3β- and lysozyme-positive cells, suggesting that Paneth cells are one of Reg3β-producing cells.
doi_str_mv	10.1080/09168451.2019.1695575
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This study investigated Reg3β-expressing cells using IL-22-stimulated enteroids. IL-22 stimulation elevated the mRNA and protein levels of Reg3β. IL-22 also increased the mRNA levels of CD133 (a transit-amplifying cell marker) and lysozyme (a Paneth cell marker). 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Inaba, Akihiko ; Iwatsuki, Ken ; Saito, Yuki ; Tadaishi, Miki ; Shimizu, Makoto ; Kobayashi-Hattori, Kazuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-6c7be11a6453b6d65a3a09c33fa6a933f0b2ce2965036ee70fc750c694edca833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Biochemistry & Molecular Biology</topic><topic>Biomarkers - metabolism</topic><topic>Biotechnology & Applied Microbiology</topic><topic>Chemistry</topic><topic>Chemistry, Applied</topic><topic>Enteroids</topic><topic>Food Science & Technology</topic><topic>IL-22</topic><topic>Interleukin-22</topic><topic>Interleukins - pharmacology</topic><topic>Lectins - biosynthesis</topic><topic>Lectins - genetics</topic><topic>Lectins - metabolism</topic><topic>Life Sciences & Biomedicine</topic><topic>Paneth cells</topic><topic>Paneth Cells - drug effects</topic><topic>Paneth Cells - metabolism</topic><topic>Physical Sciences</topic><topic>Reg3β</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sato, Mika</creatorcontrib><creatorcontrib>Inaba, Akihiko</creatorcontrib><creatorcontrib>Iwatsuki, Ken</creatorcontrib><creatorcontrib>Saito, Yuki</creatorcontrib><creatorcontrib>Tadaishi, Miki</creatorcontrib><creatorcontrib>Shimizu, Makoto</creatorcontrib><creatorcontrib>Kobayashi-Hattori, Kazuo</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, Mika</au><au>Inaba, Akihiko</au><au>Iwatsuki, Ken</au><au>Saito, Yuki</au><au>Tadaishi, Miki</au><au>Shimizu, Makoto</au><au>Kobayashi-Hattori, Kazuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of Reg3β-producing cells using IL-22-stimulated enteroids</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><stitle>BIOSCI BIOTECH BIOCH</stitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2020-03-03</date><risdate>2020</risdate><volume>84</volume><issue>3</issue><spage>594</spage><epage>597</epage><pages>594-597</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>Reg3β, a lectin, displays antibacterial activity. 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subjects	Animals Biochemistry & Molecular Biology Biomarkers - metabolism Biotechnology & Applied Microbiology Chemistry Chemistry, Applied Enteroids Food Science & Technology IL-22 Interleukin-22 Interleukins - pharmacology Lectins - biosynthesis Lectins - genetics Lectins - metabolism Life Sciences & Biomedicine Paneth cells Paneth Cells - drug effects Paneth Cells - metabolism Physical Sciences Reg3β Science & Technology
title	Identification of Reg3β-producing cells using IL-22-stimulated enteroids
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