Identification of Reg3β-producing cells using IL-22-stimulated enteroids

Identification of Reg3β-producing cells using IL-22-stimulated enteroids

Reg3β, a lectin, displays antibacterial activity. This study investigated Reg3β-expressing cells using IL-22-stimulated enteroids. IL-22 stimulation elevated the mRNA and protein levels of Reg3β. IL-22 also increased the mRNA levels of CD133 (a transit-amplifying cell marker) and lysozyme (a Paneth...

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2020-03, Vol.84 (3), p.594-597
Hauptverfasser: Sato, Mika, Inaba, Akihiko, Iwatsuki, Ken, Saito, Yuki, Tadaishi, Miki, Shimizu, Makoto, Kobayashi-Hattori, Kazuo
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biochemistry & Molecular Biology
Biomarkers - metabolism
Biotechnology & Applied Microbiology
Chemistry
Chemistry, Applied
Enteroids
Food Science & Technology
IL-22
Interleukin-22
Interleukins - pharmacology
Lectins - biosynthesis
Lectins - genetics
Lectins - metabolism
Life Sciences & Biomedicine
Paneth cells
Paneth Cells - drug effects
Paneth Cells - metabolism
Physical Sciences
Reg3β
Science & Technology
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Zusammenfassung:Reg3β, a lectin, displays antibacterial activity. This study investigated Reg3β-expressing cells using IL-22-stimulated enteroids. IL-22 stimulation elevated the mRNA and protein levels of Reg3β. IL-22 also increased the mRNA levels of CD133 (a transit-amplifying cell marker) and lysozyme (a Paneth cell marker). Immunohistochemistry showed partial colocalization of Reg3β- and lysozyme-positive cells, suggesting that Paneth cells are one of Reg3β-producing cells.
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2019.1695575