Nematocidal activity of 6-O-octanoyl- and 6-O-octyl-d-allose against larvae of Caenorhabditis elegans

The nematocidal activities of the fatty acid esters of d-allose were examined using the larvae of C. elegans. Among the fatty acid esters, 6-O-octanoyl-d-allose (3) showed significant activity. 6-O-octanoyl-d-glucose (5) showed no activity, indicating that the D-allose moiety is essential for the ne...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2019-12, Vol.83 (12), p.2194-2197
Hauptverfasser:	Sakoguchi, Hirofumi, Shintani, Tomoya, Ishiyama, Hironobu, Yanagita, Ryo C., Kawanami, Yasuhiro, Sato, Masashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antinematodal Agents - pharmacology Caenorhabditis elegans Caenorhabditis elegans - growth & development d-allose derivative Glucose - chemistry Glucose - pharmacology Larva - drug effects Nematocidal activity
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Zusammenfassung:	The nematocidal activities of the fatty acid esters of d-allose were examined using the larvae of C. elegans. Among the fatty acid esters, 6-O-octanoyl-d-allose (3) showed significant activity. 6-O-octanoyl-d-glucose (5) showed no activity, indicating that the D-allose moiety is essential for the nematocidal activity of 3. A nonhydrolyzable alkoxy analog 6-O-octyl-d-allose (6) also showed activity equivalent to that of 3.
ISSN:	0916-8451 1347-6947
DOI:	10.1080/09168451.2019.1648206