SMY2 and SYH1 suppress defects in ribosome biogenesis caused by ebp2 mutations

Ebp2 is an assembly factor of the 60S ribosomal subunit in yeast. We demonstrate that overexpression of SMY2 or SYH1 partially suppresses defects in growth and ribosome biogenesis of ebp2 mutants, and that smy2Δ and syh1Δ exhibit synthetic growth defects with the ebp2 allele. These results suggest t...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2015-09, Vol.79 (9), p.1481-1483
Hauptverfasser:	Okano, Akira, Wan, Kun, Kanda, Kazuhiro, Yabuki, Yukari, Funato, Kouichi, Mizuta, Keiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Carrier Proteins - genetics EBP2 Mutation Ribosomal Proteins ribosome biogenesis Ribosome Subunits, Large, Eukaryotic - genetics Ribosomes - genetics RNA, Ribosomal - genetics Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae Proteins - genetics SMY2 SYH1 Vesicular Transport Proteins - genetics
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Zusammenfassung:	Ebp2 is an assembly factor of the 60S ribosomal subunit in yeast. We demonstrate that overexpression of SMY2 or SYH1 partially suppresses defects in growth and ribosome biogenesis of ebp2 mutants, and that smy2Δ and syh1Δ exhibit synthetic growth defects with the ebp2 allele. These results suggest that Smy2 and Syh1 may be involved in ribosome biogenesis in relation to Ebp2.
ISSN:	0916-8451 1347-6947
DOI:	10.1080/09168451.2015.1031077