Silicone gel breast implants and connective tissue disease: A comprehensive review

Silicone breast implants have been in use for breast reconstruction and breast augmentation for a long time. In the late 80's anecdotal reports describing a possible association between silicone-gel filled breast implants, and autoimmune diseases was accumulating. Due to the growing concern abo...

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Veröffentlicht in:Autoimmunity (Chur, Switzerland) Switzerland), 2003-06, Vol.36 (4), p.193-197
Hauptverfasser: BAR-MEIR, Eran, EHERENFELD, Michael, SHOENFELD, Yehuda
Format: Artikel
Sprache:eng
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Zusammenfassung:Silicone breast implants have been in use for breast reconstruction and breast augmentation for a long time. In the late 80's anecdotal reports describing a possible association between silicone-gel filled breast implants, and autoimmune diseases was accumulating. Due to the growing concern about the safety of silicone-gel implants, the Food and Drug administration (FDA) restricted their use to participants in controlled clinical trials, including women having reconstructive surgery. However, in recent years, large meta-analyses were unable to establish an association between silicone-gel breast implants and autoimmune disease. We review the current literature, emphasizing the most important epidemiologic studies.
ISSN:0891-6934
1607-842X
DOI:10.1080/08916931000148818