Synthesis and Biophysical Studies of Modified Oligonucleotides Containing Acyclic Amino Alcohol Nucleoside Analogs

Novel serine derivative of thymine was prepared and incorporated into oligonucleotides. These modified oligonucleotides were studied for their binding affinity with complementary DNA/RNA.

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Bibliographische Detailangaben
Veröffentlicht in:	Nucleosides & nucleotides 1999-08, Vol.18 (8), p.1845-1861
Hauptverfasser:	Ramasamy, Kanda S., Stoisavljevic, Vesna
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - chemistry Magnetic Resonance Spectroscopy Nucleic Acid Denaturation Nucleic Acid Heteroduplexes - chemistry Nucleic Acid Hybridization Oligonucleotides - chemistry Phosphodiesterase I Phosphoric Diester Hydrolases - metabolism RNA - chemistry
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Novel serine derivative of thymine was prepared and incorporated into oligonucleotides. These modified oligonucleotides were studied for their binding affinity with complementary DNA/RNA.
ISSN:	0732-8311
DOI:	10.1080/07328319908044847