An Improved Deprotection Procedure of Amine-Containing Oligonucleotides from Acrylonitrile Modification
Alkylation of alkylamine by acrylonitrile via Michael addition 1 occurred when standard ammonium hydroxide deprotection was used. The alkylation was greatly reduced using an improved two-step procedure when BCE phosphotriester protecting groups were selectively removed with t-butylamine prior to amm...
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Veröffentlicht in: | Nucleosides & nucleotides 1999-06, Vol.18 (6-7), p.1205-1206 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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