Preparation of Oligonucleotides Containing Non-Natural Base Analogs

The preparation of oligonucleotides containing 5-amino-2′-deoxyuridine, 5-Nacetamido- 2′-deoxyuridine, 5-aza-2′-deoxycytidine and N 2 -substituted guanosine derivatives is described. In each case selection of the appropriate protective group, synthesis and deprotection conditions is discussed.

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Veröffentlicht in:Nucleosides & nucleotides 1997-05, Vol.16 (5-6), p.697-702
Hauptverfasser: Eritja, Ramon, Adam, Viviane, AviñTó, Anna, Díaz, Antonio R., Fàbrega, Carme, Ferrer, Elisenda, GrøStli, Morten, García, Ramón Güimil, Hofmann, Mechtild, Márquez, Víctor E., Wiersma, Marten
Format: Artikel
Sprache:eng
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Zusammenfassung:The preparation of oligonucleotides containing 5-amino-2′-deoxyuridine, 5-Nacetamido- 2′-deoxyuridine, 5-aza-2′-deoxycytidine and N 2 -substituted guanosine derivatives is described. In each case selection of the appropriate protective group, synthesis and deprotection conditions is discussed.
ISSN:0732-8311
DOI:10.1080/07328319708002936