Incorporation of 5′-N-BOC-2′, 5′-Dideoxynucleoside-3′-O-Phosphoramidites Into Oligonucleotides by Automated Synthesis

Incorporation of 5′-N-BOC-2′, 5′-Dideoxynucleoside-3′-O-Phosphoramidites Into Oligonucleotides by Automated Synthesis

An efficient method for synthesizing 5′-Boc-5′-amino-2′, 5′- dideoxynucleoside phosphoramidites and conditions for their incorporation in solid-phase oligonucleotide synthesis are presented.

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Veröffentlicht in:Nucleosides & nucleotides 1997-10, Vol.16 (10-11), p.1821-1836
Hauptverfasser: James, Kenneth D., Kiedrowski, Guenter von, Ellington, Andrew D.
Format: Artikel
Sprache:eng
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Zusammenfassung:An efficient method for synthesizing 5′-Boc-5′-amino-2′, 5′- dideoxynucleoside phosphoramidites and conditions for their incorporation in solid-phase oligonucleotide synthesis are presented.
ISSN:0732-8311
DOI:10.1080/07328319708002536