Mode of Inhibition of HIV Reverse Transcriptase- Catalyzed DNA Synthesis by 3′-Amino-3′-Deoxythymidine 5′ -Tfiphosphate

Mode of Inhibition of HIV Reverse Transcriptase- Catalyzed DNA Synthesis by 3′-Amino-3′-Deoxythymidine 5′ -Tfiphosphate

The molecular mode of action of 3′-amino-3′-deoxythymidine 5′- triphosphate in the polymerization reaction catalyzed by human immunodeficiency vim reverse transcriptase was elucidated. This compound was shown to be a termination substrate on both DNA and RNA templates.

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Veröffentlicht in:Nucleosides & nucleotides 1996-01, Vol.15 (1-3), p.655-667
Hauptverfasser: Victorova, Lyubov S., Krayevsky, Alexander A.
Format: Artikel
Sprache:eng
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Zusammenfassung:The molecular mode of action of 3′-amino-3′-deoxythymidine 5′- triphosphate in the polymerization reaction catalyzed by human immunodeficiency vim reverse transcriptase was elucidated. This compound was shown to be a termination substrate on both DNA and RNA templates.
ISSN:0732-8311
DOI:10.1080/07328319608002413